UC Santa Barbara General CatalogUniversity of California, Santa Barbara

Chemistry and Biochemistry

Division of Mathematical, Life, and Physical Sciences
Trailer 232
Telephone (805) 893-5675
Undergraduate e-mail: ugrads@chem.ucsb.edu
Graduate e-mail: gradprog@chem.ucsb.edu
Website: www.chem.ucsb.edu  
Department Chair: Frederick W. Dahlquist


 

Some courses displayed may not be offered every year.
For actual course offerings by quarter, please consult the Schedule of Classes - Class Search or GOLD (for current students).

Chemistry and Biochemistry
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Collapse Courses Lower Division 
CHEM 1A. General Chemistry
(3) STAFF
Stoichiometry, chemical reactions, gas laws, and kinetic theory, chemical equilibrium, and acid-base chemistry.
CHEM 1AL. General Chemistry Laboratory
(2) STAFF
Prerequisite: Chemistry 1A or 2A (may be taken concurrently).
Qualitative and quantitative measurements to develop laboratory technique and demonstrate the basic concepts of stoichiometry, chemical bonding, gas laws, chemical equilibrium, and acid-base chemistry.
CHEM 1B. General Chemistry
(3) STAFF
Prerequisite: Chemistry 1A or 2A with a minimum grade of C-.
Thermodynamics (1st and 2nd laws), electrochemistry, chemical kinetics, atomic and molecular structure, and chemical bonding.
CHEM 1BL. General Chemistry Laboratory
(2) STAFF
Prerequisite: Chemistry 1A or 2A with a minimum grade of C-; Chemistry 1B or 2B (may be taken concurrently).
Qualitative and quantitative measurements to develop laboratory technique and demonstrate basic concepts of thermochemistry, electrochemistry, chemical kinetics and atomic spectroscopy.
CHEM 1C. General Chemistry
(3) STAFF
Prerequisite: Chemistry 1B or 2B with a minimum grade of C-.
Chemical bonding, liquids and solids, properties of solution, structure and dynamics of elements and their compounds. Aspects of technology and environmental problems.
CHEM 1CL. General Chemistry Laboratory
(2) STAFF
Prerequisite: Chemistry 1B or 2B with a minimum grade of C-; Chemistry 1C or 2C (may be taken concurrently).
Qualitative and quantitative measurements to develop laboratory technique and demonstrate the basic concepts of solutions, intermolecular forces, colligative properties, and synthetic organic inorganic chemistry.
CHEM 2A. General Chemistry (Honors)
(3) STAFF
The sequence of topics will be similar to that in Chemistry 1A. Calculus will be used as needed, at the level of the concurrent Mathematics 3A course.
CHEM 2AC. General Chemistry Laboratory (Honors)
(2) STAFF
Prerequisite: Chemistry 2A (may be taken concurrently).
Qualitative and quantitative measurements to develop laboratory technique and demonstate the basic concepts of stoichiometry, chemical bonding, gas laws, chemical equilibrium, and acid-base chemistry. Students work in small groups to develop a unique perspective on the experiment.
CHEM 2B. General Chemistry (Honors)
(3) STAFF
Prerequisite: Chemistry 2A or 1A with a minimum grade of B.
Thermodynamics (first and second law), electrochemistry, chemical kinetics, atomic and molecular structure, and chemical bonding.
CHEM 2BC. General Chemistry Laboratory (Honors)
(2) STAFF
Prerequisite: Chemistry 2A or 1A with a minimum grade of B; Chemistry 2AC or 1AL with a minimum grade of B; and Chemistry 2B (may be taken concurrently).
Laboratory techniques. Thermochemistry, electrochemistry, chemical kinetics, and atomic spectroscopy. Students work in small groups to develop a unique perspective on the experiment.
CHEM 2C. General Chemistry (Honors)
(3) STAFF
Prerequisite: Chemistry 2B or 1B with a minimum grade of B.
Structure and dynamics of the elements and their compounds. Aspects of technology and environmental problems.
CHEM 2CC. General Chemistry Laboratory (Honors)
(2) STAFF
Prerequisite: Chemistry 2B or 1B with a minimum grade of B; and Chemistry 2BC or 1BLwith a minimum grade of B; and Chemistry 2C (may be taken concurrently).
Laboratory techniques. Solutions, colligative properties, and synthetic organic and inorganic chemistry. Students work in small groups to develop a unique perspective on the experiment.
CHEM 6AL. Laboratory Methods of Organic Chemistry
(3) STAFF
Prerequisite: Chemistry 109A or 109AH (may be taken concurrently).
Distillation, crystallization, extraction, determination of physical properties, spectroscopy, and instrumental methods in organic chemistry.
CHEM 6BH. Laboratory Methods of Organic Chemistry (Independent Research)
(3) STAFF
Prerequisite: Chemistry 6A and 109A; and Chemistry 109B (may be taken concurrently); open to chemistry, biochemistry and creative studies majors only; consent of instructor.
Independent research involving distillation, crystallization, extraction, determination of physical properties, organic synthesis, and use of instrumental methods in organic chemistry.
CHEM 6BL. Laboratory Methods of Organic Chemistry
(3) STAFF
Prerequisite: Chemistry 6AL and 109A or 109AH with a minimum grade of C-; and Chemistry 109B or 109BH (may be taken concurrently).
Distillation, crystallization, extraction, determination of physical properties, organic synthesis, instrumental methods in organic chemistry.
CHEM 6CH. Organic Chemistry Labs
(3) STAFF
Prerequisite: Chemistry 6B and 109B; and Chemistry 109C (may be taken concurrently); open to chemistry, biochemistry and creative studies majors only; consent of instructor.
Independent research involving distillation, crystallization, extraction, determination of physical properties, organic synthesis, and use of instrumental methods in organic chemistry for the purposes of multistep synthesis.
CHEM 6CL. Organic Chemistry Labs
(3) STAFF
Prerequisite: Chemistry 6BL and 109B or 109BH with a minimum grade of C-; and Chemistry 109C or 109CH (may be taken concurrently).
Distillation, crystallization, extraction, determination of physical properties, organic synthesis, instrumental methods in organic chemistry.
CHEM 10. Introduction to Computer Methods and Simulations in Chemistry
(2) STAFF
Introduction of different computing techniques for scientific computation in the fields of chemistry, materials, and nanotechnology using Unix and web based software. Applications include: molecular modeling, molecular dynamics, Mathematica, Monte Carlo, data analysis, quantum computing, and data mining.
CHEM 99. Introduction to Research
(1-3) STAFF
Prerequisite: Consent of instructor.
Directed study, normally experimental, to be arranged with individual faculty members. Course offers exceptional students an opportunity to participate in a research group. Basic techniques and the operation of instruments used in research. A few students in chemistry are quite advanced having had extensive laboratory training in high school or elsewhere. This course allows them the opportunity to participate in a research group before they acquire 84 units and are then eligible for and capable of handling 199, Independent Studies.
Collapse Courses Upper Division 
CHEM 102. Chemistry in the Community / The Process of Learning and Teaching Science
(4) VAN KOPPEN
Prerequisite: Chemistry 1A-AL, 1B-BL, 1C-CL
Students work with fifth graders to teach hands-on physical science activities in our chemistry labs. They also work with teachers in the classroom to implement science lesson plans. They observe how students learn science and share their experiences with one another.
CHEM 109A. Organic Chemistry
(4) STAFF
Prerequisite: Chemistry 1C or 2C with a minimum grade of C-; or Chemistry 1B or 2B with a minimum grade of B-.
Structure, reactivity and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acides, proteins, nucleic acids, coenzymes and their mechanisms.
CHEM 109AH. Organic Chemistry (H)
(4) STAFF
Prerequisite: Chemistry 1B/2B or 1C/2C with a minimum grade of B.
Structure, nomenclature, stereochemistry, and reactivity of organic molecules. Suitable for undergraduates requiring strong understanding of organic chemistry and possessing strong background in science, such as honors students, majors in chemistry, biochemistry-chem, chemical engineering, etc. This course cannot be repeated.
CHEM 109B. Organic Chemistry
(4) STAFF
Prerequisite: Chemistry 109A with a minimum grade of C-.
Structure, reactivity and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acides, proteins, nucleic acids, coenzymes and their mechanisms.
CHEM 109BH. Organic Chemistry (H)
(4) STAFF
Prerequisite: Chemistry 109A with a minimum grade of B+ or Chemistry 109AH with a minimum grade of B.
Structure, nomenclature, stereochemistry, and reactivity of organic molecules. Suitable for undergraduates requiring strong understanding of organic chemistry and possessing strong background in science, such as honors students, majors in chemistry, biochemistry-chem, chemical engineering, etc. This course cannot be repeated.
CHEM 109C. Organic Chemistry
(4) STAFF
Prerequisite: Chemistry 109B with a minimum grade of C-.
Structure, reactivity and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acides, proteins, nucleic acids, coenzymes and their mechanisms.
CHEM 109CH. Organic Chemistry (H)
(4) STAFF
Prerequisite: Chemistry 109B with a minimum grade of B+ or Chemistry 109BH with a minimum grade of B.
Structure, reactivity, mechanisms, synthesis, nomenclature, and spectroscopic identification of the principal classes of organic compounds as well as organometallics, amino acids, proteins, and carbohydrates. This course is intended for chemistry majors and others requiring a strong basis in organic chemistry.
CHEM 110L. Introductory Biochemistry Laboratory
(4) STAFF
Prerequisite: Chemistry 142A (may be taken concurrently).
Gives students hands-on experience with modern methods of separation, identification, and study of biomolecules and macromolecular structures. Focus is on techniques but the course also gives an introduction to computer-based bioinformatics tools.
CHEM 111. Chemical Kinetics
(3) STAFF
Prerequisite: Consent of instructor.
The laws and theories governing rates of chemical reactions and reaction mechanisms. Empirical treatment of reaction rates, treatment of data, gas-phase reactions, reactions in solution, catalysis, complex reactions, chain reactions. Collision theory and potential energy surfaces.
CHEM 112A. Biophysical Chemistry
(4) BROWN, SHEA, DAHLQUIST
Prerequisite: Chemistry 1C or 2C; and, Mathematics 3A-B, 4A or 3C, and 6A or 5A; and, Physics 1, 2, 3, 3L, 4, and 4L, or, Physics 6A- AL-B-BL-C-CL; Chemistry 142A or MCDB 108A (may be taken concurrently).
Laws of thermodynamics, chemical equilibria and ligand binding, phase equilibria, electrochemistry, nonelectrolyte solutions, applications to biochemical problems.
CHEM 112B. Biophysical Chemistry
(4) BROWN, SHEA, DAHLQUIST
Prerequisite: Chemistry 112A; Chemistry 142B (may be taken concurrently).
Forces influencing macromolecular conformation, microscopy and diffraction methods, quantum mechanics, statistical mechanics.
CHEM 112C. Biophysical Chemistry
(4) BROWN, SHEA, DAHLQUIST
Prerequisite: Chemistry 112B; Chemistry 142A-B, or, MCDB 108A-B; Chemistry 142C, or, MCDB 108C (may be taken concurrently).
Biological spectroscopy, nuclear magnetic resonance, mass transport dynamics in solution, chemical and biochemical kinetics.
CHEM 112L. Biophysical and Bioanalytical Laboratory
(3) STAFF
Prerequisite: Chemistry 110L, 113A or 112A, and 142A-B-C (Chem 142C may be taken concurrently).
Application of modern biophysical and bioanalytical techniques to study the structure, function, and properties of biomolecules. Fluorescence spectroscopy, mass spectroscopy, FTIR, 2D-NMR, diffraction techniques, circular dichroism.
CHEM 113A. Physical Chemistry
(4) BOWERS, BURATTO, HARRIS, METIU
Prerequisite: Chemistry 1C or 2C; and, Mathematics 3A-B, 4A or 3C, and 6A or 5A; and, Physics 1, 2, 3, 3L, 4, and 4L, or, Physics 6A- AL-B-BL-C-CL.
Chemical thermodynamics: laws of thermodynamics, phase equilibria, chemical equilibria, equations of state.
CHEM 113B. Physical Chemistry
(4) BOWERS, BURATTO, HARRIS, METIU
Prerequisite: Chemistry 113A or Chemical Engineering 110A-B.
Quantum theory and spectroscopy: introduction to quantum mechanics; symmetry, molecular structure, and spectroscopy.
CHEM 113C. Physical Chemistry
(4) BOWERS, BURATTO, HARRIS, METIU
Prerequisite: Chemistry 113B.
Kinetic theory of gases, chemical kinetics, statistical mechanics, photochemistry.
CHEM 115A. Fundamentals of Quantum Chemistry
(3) KIRTMAN, WODTKE
Prerequisite: Mathematics 5A, and Chemistry 113A-B-C or Chemistry 112A-B-C.
Introduction to quantum mechanics-postulatory approach; particle in box, on ring, harmonic oscillator; linear operator theory, matrix algebra; hydrogen atom; perturbation theory, variation theory; applications.
CHEM 115B. Fundamentals of Quantum Chemistry
(3) KIRTMAN, WODTKE
Prerequisite: Chemistry 113A-B-C or Chemistry 112A-B-C, Mathematics 5A.
Molecular orbital theory and valence bond theory; Huckel theory (secular eqn.) applications to conjugated systems, electronic spectra, and term symbols; introduction to infrared, Raman, and microwave spectroscopy.
CHEM 115C. Fundamentals of Quantum Chemistry
(3) KIRTMAN, WODTKE
Prerequisite: Chemistry 113A-B-C or Chemistry 112A-B-C, Mathematics 5A.
Introduction to NMR, EPR, group theory; applications.
CHEM 116AL. Quantitative Analytical and Physical Methods Laboratory
(3) BURATTO, DEVRIES, LAVERMAN
Prerequisite: Chemistry 150 (may be taken concurrently); Chemistry 113B (may be taken concurrently).
Principles of analytical chemistry including spectroscopy, classical techniques and separation processes. Quantitative analysis of unknowns. Introduction to instrumental analysis.
CHEM 116BL. Advanced Physical Chemistry Laboratory
(3) LAVERMAN
Prerequisite: Chemistry 150 and 116AL; Chemistry 113C (may be taken concurrently).
Experiments in thermodynamics, spectroscopy, and electrochemistry. Synthesis and study of inorganic complexes. Instrumental techniques such as NMR, fluorescence, Raman and laser flash photolysis are explored. Methods of data and error analysis.
CHEM 116CL. Inorganic Synthesis and Physical Characterization Laboratory
(3) LAVERMAN
Prerequisite: Chemistry 150 and 116BL; Chemistry 173A (may be taken concurrently).
Synthesis of inorganic and organometallic complexes including techniques for air-sensitive materials. Instrumental characterization and study of synthesized compounds in a research-like setting.
CHEM 117A. Statistical Mechanics
(3) BROWN, METIU, SHEA
Prerequisite: Chemistry 113A-B-C or Chemistry 112A-B-C.
Fundamentals of statistical thermodynamics, partition functions for ideal gases and crystals, quantum statistics, calculations of thermodynamic properties.
CHEM 118. Photochemistry and Radiation Chemistry
(3) BURATTO
Prerequisite: Chemistry 113A-B-C or Chemistry 112A-B-C; and 150.
Interaction of light and matter, reaction paths from electronically excited molecules, flash photolysis, high energy radiation.
CHEM 123. Fundamentals of Environmental Chemistry
(3) DE VRIES, PERONA
Prerequisite: Chemistry 1A-B.
Study of Earth's biogeochemical cycles with respect to carbon, nitrogen, and sulfur. Introduction to the science of climate change, including effects of global warming on terrestrial and aquatic ecosystems. Environmental impacts of fossil fuel and biofuel technologies. Chemistry of the atmosphere, hydrosphere, and lithosphere, with emphasis on ozone depletion, photochemical smog, acid rain, global ocean acidification, soil and groundwater contamination, and environmental costs of industrialized agriculture.
CHEM 124. Organic Spectroscopic Analysis
(3) STAFF
Prerequisite: Chemistry 107A-B or 109A-B; and Chemistry 6A.
Structure determination of complex organic molecules. Topics covered include NMR, IR, UV, and mass spectrometry.
CHEM 125L. Laboratory Techniques in Biochemistry
(4) STAFF
Prerequisite: Chemistry 110L; and Chemistry 142A-B (may be taken concurrently).
Application of molecular biology techniques to perform mutagenesis and cloning; restriction endonucleases, PCR, plasmid purification and DNA analysis. Protein purification and analysis methods: expression of proteins in bacterial systems.
CHEM 126. Computation Chemistry and Molecular Modeling
(3) AUE, GERIG
Prerequisite: Chemistry 109A-B.
Introduction to computational chemistry and molecular modeling. Application of molecular mechanics, quantum mechanics and computer graphical interfaces to problems in chemistry, biochemistry, drug design and pharmacology.
CHEM 127. Structure and Reactivity in Organic Chemistry
(3) STAFF
Prerequisite: Chemistry 107A-B-C or 109A-B-C with a C or better.
Electronic structure, resonance, acid/base chemistry, thermodynamics, kinetics, transition state theory, and isotope effects.
CHEM 128. Organic Reaction Mechanisms
(3) STAFF
Prerequisite: Chemistry 107A-B-C or 109A-B-C.
Mechanisms of thermal, photochemical, organometallic, electrochemical asymmetric or other processes in organic chemistry.
CHEM 129. Synthetic Organic Reactions
(3) STAFF
Prerequisite: Chemistry 107A-B-C or 109A-B-C.
A survey of reactions of organic substances with emphasis on those with practical synthetic utility, including discussion of mechanism, scope and limitations, and steriochemical issues.
CHEM 132. Organometallics in Organic Synthesis
(3) STAFF
Prerequisite: Chemistry 109A-B-C and Chemistry 129; upper-division standing.
Synthetic methods and applications to natural products total syntheses involving transition metals.
CHEM 133. Advanced Synthetic Chemistry
(3) STAFF
Prerequisite: Chemistry 109A-B-C; upper-division standing; open to chemistry and biochemistry majors only.
A comprehensive discussion of modern synthetic organic methods, including the applications of addition, condensation, substitution, and rearrangement reactions.
CHEM 134. Chemical Synthesis of Biological Molecules
(3) STAFF
Prerequisite: Chemistry 129; upper-division standing.
The synthesis, manipulation, and modification of biological molecules including peptides, carbohydrates, nucleic acids, and other metabolites are essential to advances in biomedicine. This course surveys chemical methods for the production of these molecules and their application to biological problems.
CHEM 141. Epigenetics: Biology, Mechanisms and Therapies
(3) REICH
Prerequisite: Chemistry 142A-B-C or MCDB 108A-B-C; upper-division standing.
Covers epigenetic processes and molecular mechanisms in bacteria, fungi, plants, mammals, imprinting, gene regulation, repeat-induced point mutation (RIP), X- chromosome inactivation, epigenetic mechanisms including DNA methylation, histone modification, chromatin remodeling, RNA silencing, and epigentically based therapeutics and pharmaco-epigenetics.
CHEM 142A. Biochemistry
(3) REICH, PERONA, PARSONS
Prerequisite: Chemistry 107A-B-C or 109A or 109AH-109B or 109BH-109C or 109CH
Macromolecules of biological importance. A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of biomolecules.
CHEM 142AH. Biochemistry-Honors Discussion
(1) REICH
Prerequisite: Concurrent enrollment in Chem 142A.
Discussion sections using science articles to convey “how science gets done” and its limitations. Students learn how to read science papers, the publication process, resources for finding papers and how to dissect them into experiments and conclusions. Students attend research seminars and group meetings involving presentations by Chemistry & Biochemistry graduate students.
CHEM 142B. Biochemistry
(3) PARSONS, REICH, PERONA
Prerequisite: Chemistry 142A.
Chemical aspects of intermediary metabolism. The chemistry and elementary dynamic properties of enzymes; study of enzyme active sites; characterization of metabolic pathways and methods of examining cellular regulation.
CHEM 142BH. Biochemistry-Honors Discussion
(1) REICH
Prerequisite: Concurrent enrollment in Chem 142B.
Discussion sections using science articles to convey “how science gets done” and its limitations. Students learn how to read science papers, the publication process, resources for finding papers and how to dissect them into experiments and conclusions. Students will attend research seminars and group meetings involving presentations by Chemistry & Biochemistry graduate students.
CHEM 142C. Biochemistry
(3) PARSONS, REICH, PERONA
Prerequisite: Chemistry 142B.
Macromolecular biosynthesis and specialized cellular processes. A survey ofnucleic acid and protein biosynthesis, characterization of lipids and membranes; function of membranes in transport, energy transduction, and cellular control; mechanisms of muscle contraction and cell motility.
CHEM 142CH. Biochemistry-Honors Discussion
(1) REICH
Prerequisite: Concurrent enrollment in Chem 142C.
Discussion sections using science articles to convey “how science gets done” and its limitations. Students learn how to read science papers, the publication process, resources for finding papers and how to dissect them into experiments and conclusions. Students will attend research seminars and group meetings involving presentations by Chemistry & Biochemistry graduate students.
CHEM 143. The RNA World
(3) STAFF
Prerequisite: Chemistry 142A-B-C; or, MCDB 108A-B-C.
Introduction to RNA structure and thermodynamics. Biological roles of RNA in contemporary organisms. Implications for the origins of life.
CHEM 145. Computational Biochemistry
(3) GERIG, PERONA, SHEA
Prerequisite: Chemistry 113A-B or Chemistry 112A-B; and, Chemistry 142A or MCDB 108A.
Introduction to molecular modeling and molecular dynamics. Discussion of practical considerations of energy minimization, solvent modeling, structure- based drug design. Practical computer graphics experience.
CHEM 146. Membrane Biochemistry
(3) PARSONS, REICH
Prerequisite: Chemistry 142A-B, or MCDB 108A-B-C.
Introduction to the structures and roles of lipids an their phase behavior,liposomes, membrane proteins and kinetics, protein sorting, and signal transduction.
CHEM 147. Astrobiology and the Origins of Life
(3) PLAXCO
Prerequisite: Chemistry 142A.
Discusses the origins and evolution of the solar system and the earth, the origins and evolution of life on earth, and the possibilities for life elsewhere in the cosmos all from the perspective of contemporary, terrain biochemistry.
CHEM 150. Analytical Chemistry
(3) BURATTO, STROUSE
Prerequisite: Chemistry 1A-B-C or 2A-B-C.
Principles of analytical chemistry including classical techniques, spectrophotochemistry, electroanalytical techniques, and separation processes.
CHEM 151. Post-translational Protein Processing
(4) WAITE
Prerequisite: MCDB 108A or Chemistry 142A with a grade of C or better.
Structure/function relationships in interesting macromolecules isolated from marine organisms. Focus is on well-characterized pathways from horseshoe crabs, abolones, mussels, and fish as well as others.
CHEM 153. Advanced Analytical Techniques
(3) STROUSE
Prerequisite: Chemistry 150.
Principles of analytical methodology, as in spectroscopy, electroanalysis, and chromatography. Applications to environmental problems, forensic and clinical analysis, and industry. Analysis of solids and surfaces.
CHEM 154A. Magnetic Resonance in Biological Systems
(3) STAFF
Prerequisite: Chemistry 113A-B or Chemistry 112A-B; and, Chemistry 112C or 113C (may be taken concurrently).
A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.
CHEM 154B. Magnetic Resonance in Biological Systems
(3) STAFF
Prerequisite: Chemistry 113A-B or Chemistry 112A-B; and, Chemistry 112C or 113C (may be taken concurrently).
A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.
CHEM 161. Enzyme Mechanisms
(3) REICH
Prerequisite: Chemistry 142A-B-C; or MCDB 108A-B-C.
Chemistry, structure and function of enzymes; theory, experimental design, and data analysis. Enzyme models and non-classical enzymes.
CHEM 162A. Drug Design
(3) KAHN, REICH
Prerequisite: Chemistry 142A-B-C or MCDB 108A-B-C.
Sources for new drugs. Biochemistry of diseases. Target validation techniques. Mechanism of action of enzymes and receptors. Enzyme inhibition and receptor binding studies. Structure based drug design: conformational analysis, docking and binding affinity calculations. Course also teaches proposal writing skills.
CHEM 162B. Drug Design
(3) KAHN, REICH
Prerequisite: Chemistry 142A-B-C or MCDB 108A-B-C.
Medical chemistry for lead optimization, combinatorial synthesis, quantitative structure-activity relationships, pharmocokinetics, drug metabolism and toxicity, pharmacogenomics. Drugs that interact with DNA and protein drugs. Clinical trials, intellectual property in drug design. Students develop their own drug design project.
CHEM 163. Arrow Pushing in Organic Chemistry
(2) STAFF
Prerequisite: Chemistry 109A-B-C; upper-division standing; open to chemistry and biochemistry majors only.
Covers the arrow pushing formulasism and addresses molecular rearrangements and other organic reactions from this perspective.
CHEM 171. Bioinorganic Chemistry
(3) BUTLER
Prerequisite: Chemistry 173A.
Selected topics in bioinorganic chemistry, and metallo-biochemistry. Discussions of metalloproteins and corresponding model compound investigations. Emphasis will be on reaction mechanisms and spectroscopy or properties of metal sites.
CHEM 173A. Advanced Inorganic Chemistry
(3) STAFF
Prerequisite: Chemistry 113A-B-C, or Chemistry 112A-B-C.
Electronic structure of atoms and molecules. Models for bonding in molecules of nontransition and transition elements. Applications of symmetry to bonding, electronic and vibrational spectroscopy. Stereochemistry of transition metal complexes and introduction to organometallics.
CHEM 173B. Advanced Inorganic Chemistry
(3) STAFF
Prerequisite: Chemistry 173A.
Structures of ordered crystalline solids, X-Ray crystallography. Introduction to solid state chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry.
CHEM 175. Physical-Inorganic Chemistry
(3) FORD, STROUSE, WATTS
Prerequisite: Chemistry 173A-B.
Bounding theory, thermodynamics, and structure of inorganic compounds. Applications of physical techniques to the study of inorganic (and organometallic) reactions and their mechanisms.
CHEM 176. Photochemical and Photophysical Properties of Inorganic and Organometallic Compounds and Materials
(3) FORD, STUCKY, WATTS
Prerequisite: Chemistry 173A.
Discussion of the mechanisms of fundamental physical and chemical events which follow absorption of light by inorganic and organometallic chromophores. Consideration of homogeneous and heterogeneous systems as well as the design and operation of photo-optical and photoelectrical devices.
CHEM 181. Protein Crystallography
(3) KOHLSTAEDT, PERONA
Prerequisite: Consent of instructor.
Introduction to diffraction techniques. Protein crystal growth and morphology. Data collection and reduction strategies. Approaches for solving the phase problem. Crystallographic refinement, including molecular dynamics. Interpretation of crystal structures.
CHEM 183. Introduction to Teaching in Chemistry
(1-5) VAN KOPPEN
Prerequisite: Upper-division standing, a chemistry grade point average of 3.5 or above and consent of instructor.
Students will assist instructor in teaching a lab course in which the student previously received a grade of A- or better. Activities will be determined in consultation with the instructor and include instruction of 1 or 2 lab sections per week, hold 1 office hour per week, prepare weekly quizzes and lab lectures, grade weekly lab reports and quizzes, conduct one review session for the lab final, maintain/submit student grade records, complete video tape teaching evaluation and consultation with instructional development, complete mid-quarter and end of quarter teaching evaluations, grade and proctor exams.
CHEM 184. Chemical Literature
(2) HUBER
Prerequisite: 3 prior courses in chemistry.
Lectures and exercises on the literature and other information resources of use in chemistry.
CHEM 192. Honors Research Seminar
(3) STAFF
Prerequisite: Upper-division standing; consent of instructor and department.
Independent research project carried out under the supervision of faculty member. Goal is to write an original, publishable, research paper. The project can be on a topic of the student's choice, or it can be an extension of an ongoing research project under the direction of a faculty member in the department.
CHEM 193. Internship in Chemistry
(1-4) STAFF
Prerequisite: Consent of instructor.
Opportunity to obtain practical non paid chemistry-related research and work experience by working under faculty and/or staff direction as an intern.
CHEM 199. Independent Studies
(1-5) STAFF
Prerequisite: Upper-division standing in the major; completion of two upper division courin chemistry.
Coursework shall consist of academic research supervised by a faculty member. This course is not intended for internship credit.
Collapse Courses Graduate 
CHEM 217A. Statistical Mechanics
(3) BROWN, METIU, SHEA
Prerequisite: Consent of graduate advisor.
Fundamentals of statistical thermodynamics, partition functions for ideal gases and crystals, quantum statistics, calculations of thermodynamic properties.
CHEM 217B. Statistical Mechanics
(3) BROWN, METIU, SHEA
Prerequisite: Consent of graduate advisor.
Fundamentals of non-equilibrium statistical mechanics, kinetic theory of gases, Boltzmann equation, correlation functions, linear response theory, fluctuation-dissipation theorem, Langevin and Fokker-Planck equations.
CHEM 217C. Statistical Mechanics
(3) BROWN, METIU, SHEA
Prerequisite: Consent of graduate advisor.
Selected topics in advanced statistical mechanics. Phase transitions and the renormalization group. Theory of rate processes.
CHEM 218. Photochemistry and Radiation Chemistry
(3) BURATTO
Prerequisite: Open only by consent of the chemistry graduate advisor.
Interaction of light and matter, reaction paths from electonically excited molecules, flash photolysis, high energy radiation.
CHEM 219. Selected Topics in Physical Chemistry
(1-4) STAFF
Prerequisite: Consent of instructor.
Selected topics: orbital symmetry rules for chemical reactions (Pearson); classical theory of light, radiation, and spectroscopy (Metiu); nonlinear optics and nonlinear spectroscopy (Metiu).
CHEM 222A. Fundamentals of Quantum Chemistry
(3) KIRTMAN, PALKE
Prerequisite: Consent of the graduate advisor. Graduate standing.
Introduction to quantum mechanics-postulatory approach; particle in box, on ring, harmonic oscillator; lineral operator theory, matrix algebra; hydrogen atom; perturbation theory, variation theory; applications.
CHEM 222B. Fundamentals of Quantum Chemistry
(3) KIRTMAN, PALKE
Prerequisite: Consent of the graduate advisor. Graduate standing.
Molecular Orbital theory and Valence Bond theory (Secular Equ.) applications to conjugated systems, electronic spectra, and term symbols; introduction to infrared, raman, and microwave spectroscopy.
CHEM 222C. Fundamentals of Quantum Chemistry
(3) KIRTMAN, PALKE
Prerequisite: Consent of the graduate advisor. Graduate standing.
Introduction to NMR, EPR, group theory; applications.
CHEM 223. Current Events in Organic Chemistry
(2) STAFF
Faculty and students present and critically discuss current chemical literature.
CHEM 224. Organic Spectroscopic Analysis
(3) STAFF
Structure determination of complex organic molecules. Topics include NMR, IR, UV, and mass spectrometry.
CHEM 225. Instrumental Methods in Physical Chemistry
(3) BOWERS, WODTKE
Prerequisite: Consent of instructor.
Fundamentals of basic measurements and advanced research instrumentation are taught. Emphasis is on both practical and conceptual understanding of the methods, suitable for experimental design. Signal electronics, vacuum techniques, molecularbeams, lasers, and optics.
CHEM 226. Computational Chemistry
(3) AUE, GERIG
Introduction to computational chemistry and molecular modeling. Applications of molecular mechanics, quantum mechanics, and computer graphical interfaces to problems in chemistry, biochemistry, drug design, and pharmacology.
CHEM 227. Structure and Reactivity in Organic Chemistry
(3) STAFF
Electronic structure, resonance, acid/base chemistry, thermodynamics, kinetics, transition state theory, and isotope effects.
CHEM 228. Organic Reaction Mechanisms
(3) STAFF
Mechanisms of thermal, photochemical, organometallic, electrochemical, asymmetric or other processes in organic chemistry.
CHEM 229. Synthetic Organic Reactions
(3) STAFF
A survey of reactions of organic substances with emphasis on those with practical synthetic utility, including discussion of mechanism, scope and limitations, and stereochemical issues.
CHEM 232. Organometallics in Organic Synthesis
(3) STAFF
Prerequisite: Chemistry 109A-B-C; and, Chemistry 129 or 229; graduate standing.
Synthetic methods and applications to natural products total syntheses involving transition metals.
CHEM 233. Advanced Synthetic Chemistry
(3) STAFF
Prerequisite: Consent of instructor.
A comprehensive discussion of modern synthetic organic methods, including the applications of addition, condensation, substitution, and rearrangement reactions.
CHEM 234. Chemical Synthesis of Biological Molecules
(3) STAFF
Prerequisite: Chemistry 229; graduate standing; consent of instructor.
The synthesis, manipulation, and modification of biological molecules including peptides, carbohydrates, nucleic acids, and other metabolites are essential to advances in biomedicine. This course surveys chemical methods for the production of these molecules and their application to biological problems.
CHEM 239. Selected Topics in Organic Chemistry
(1-4) STAFF
Prerequisite: Consent of instructor.
Selected topics from organic chemistry the contents of this course will vary.
CHEM 240. Chemistry of Organic Semiconductors
(4) BAZAN
Synthesis, electronic structure, photophysics and applications of organic semiconductors. Emphasis will be placed on materials based on conjugated polymers. Applications of interest include solar cell devices, biosensors, and light emitting diodes.
CHEM 241. Epigenetics: Biology, Mechanisms and Therapies
(3) REICH
Prerequisite: Chemistry 142A-B-C or MCDB 108A-B-C; graduate standing.
Covers epigenetic processes and molecular mechanisms in bacteria, fungi, plants, mammals, imprinting, gene regulation, repeat-induced point mutation (RIP), X- chromosome inactivation, epigenetic mechanisms including DNA methylation, histone modification, chromatin remodeling, RNA silencing, and epigentically based therapeutics and pharmaco-epigenetics.
CHEM 242A. Chemical Aspects of Biological Systems
(3) STAFF
Prerequisite: Open only by consent of the chemistry graduate advisor.
Macromolecules of biological importance. A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of biomolecules.
CHEM 242B. Chemical Aspects of Biological Systems
(3) STAFF
Prerequisite: Open only by consent of the chemistry graduate advisor.
Chemical aspects of intermediary metabolism. The chemistry and elementary dynamic properties of enzymes; study of enzyme active sites; characterization of metabolic pathways and methods of examining cellular regulation.
CHEM 242C. Chemical Aspects of Biological Systems
(3) STAFF
Prerequisite: Open only by consent of the chemistry graduate advisor.
Macromolecular biosynthesis and specialized cellular processes. A survey of nucleic acid and protein biosynthesis, characterization of lipids and membranes; function of membranes in transport, energy transduction, and cellular control; mechanisms of muscle contraction and cell motility; neurochemistry.
CHEM 243. The RNA World
(3) PERONA
Prerequisite: Chemistry 142A-B-C; or, MCDB 108A-B-C.
Introduction to RNA structure and thermodynamics. Biological roles of RNA in contemporary organisms. Implications for the origins of life.
CHEM 244. Informational Macro- and Supra-Molecules
(2) JAEGER
Prerequisite: Consent of instructor.
Selected topics at the interface of chemistry and biology; informational molecular coding, molecular machines, self-assembling and self-replicating molecular systems, evolution and selection of molecules with binding and catalytic properties, biopolymer-based materials, special emphasis on cutting-edge technologies.
CHEM 245. Computational Biochemistry
(3) STAFF
Prerequisite: Chemistry 113A, 112, 142A-B-C or 113A-B-C.
Introduction to molecular modeling and molecular dynamics. Discussion of practical considerations of energy minimization, solvent modeling, structure-based drug design. Practical computer graphics experience.
CHEM 246. Membrane Biochemistry
(3) PARSONS, REICH
Prerequisite: Chemistry 142A-B-C.
Introduction to the structures and roles of lipids an their behavior, liposomes, membrane proteins and kinetics, protein sorting, and signal transduction.
CHEM 248. Reaction Rate Theory
(3) PETERS
Advanced theoretical and computational methods for the analysis of reaction kinetics and mechanisms. Topics include transition state theory, Kramers' theory, tunneling effects, transition state search algorithms, transition path sampling, kinetic Monte Carlo, reaction coordinate and degree-of-rate-control analyses.
CHEM 251. Post-Translational Protein Processing
(4) WAITE
Prerequisite: MCDB 108A or MCDB 218A or Chemistry 142A or equivalent.
Structure/function relationships in interesting macromolecules isolated from marine organisms. Focus is on well-characterized pathways from horseshoe crabs, abalones, mussels, and fish as well as others.
CHEM 254A. Magnetic Resonance in Biological Systems
(3) STAFF
Prerequisite: Graduate standing.
A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.
CHEM 254B. Magnetic Resonance Techniques in Biological Systems
(3) GERIG
Prerequisite: Consent of instructor.
A discussion of the theory and practice of magnetic resonance methods currently used in studies of proteins, nucleic acids, and polysaccharides both individually and in complex structures such as membranes. nmr and epr techniques will be included but the emphasis will be on high-resolution 1H and 13C spectroscopy.
CHEM 257. Stategy in Organic Synthesis and Methodology
(3) STAFF
Prerequisite: Advancement to candidacy.
The design, development, presentation, and organization of new concepts for organic synthesis and methodologies is an essential skill for graduate students. Course focuses on advances in these areas and developng skills for writing and presenting research proposals.
CHEM 259. Selected Topics in Biological Chemistry
(1-4) STAFF
Prerequisite: Consent of instructor.
Selected topics from bio-organic, biophysical, or biological chemistry. Thecontent of this course will vary.
CHEM 261. Enzyme Mechanisms
(3) PARSONS
Prerequisite: Chemistry 142A-B-C or MCDB 108A-B-C.
Chemistry, structure, and function of enzymes; theory, experimental design,and data analysis. Enzyme models and non-classical enzymes.
CHEM 262A. Drug Design
(3) KAHN, REICH
Sources for new drugs. Biochemistry of diseases. Target validation techniques. Mechanism of action of enzymes and receptors. Enzyme inhibition and receptor binding studies. Structure base drug design: conformational analysis, docking and binding affinity calculations. Course also teaches proposal writing skills.
CHEM 262B. Drug Design
(3) KAHN, REICH
Medicinal chemistry for lead optimization, combinatorial synthesis, quantitative structure-activity relationships, pharmacokinetics, drug metabolism and toxicity, pharmacogenomics. Drugs that interact with DNA and Protein drugs. Clinical trials, intellectual property in drug design. Students develop their own drug design project.
CHEM 263. Arrow Pushing in Organic Chemistry
(2) STAFF
Prerequisite: Graduate standing.
Covers the arrow pushing fomulasism and addresses molecular rearrangements and other organic reactions from this perspective.
CHEM 265. Industrial Methods for Polymer Synthesis
(3) BAZAN
Prerequisite: Graduate or senior standing.
Covers in detail the methods of polymer preparation currently practiced in industry. Special coverage of structure/property relationships in polymers, the design and mechanism of action of successful catalysts, and the transformation of basic polymerization reactions into large-scale processes.
CHEM 266. Photophysics and Device Science of Organic Materials
(3) STAFF
Prerequisite: Graduate or senior standing.
Examination of what happens when organic molecules absorb a photon or when they are incorporated within an optoelectric device. Specific subjects include phtoexcitation and relaxation processes, energy transfer, flourescence depolarization, the design of flourescence-based biosensors, organic light emitting diodes and field effect transistors.
CHEM 268A. Advanced Inorganic Chemistry
(3) STAFF
Prerequisite: Consent of the chemistry graduate advisor.
Electronic structure of atoms and molecules. Models for bonding in molecules of nontransition and transition elements. Applications of symmetry to bonding, electronic and vibrational spectroscopy. Stereochemistry of transition metal complexes and introduction to organo- metallics.
CHEM 268B. Advanced Inorganic Chemistry
(3) STAFF
Prerequisite: Consent of the chemistry graduate advisor.
Structures of ordered crystalline solids, x-ray crystallography. Introduction to solid state chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry.
CHEM 270. Graduate Seminar in Inorganic/Analytical Chemistry
(2) STAFF
Prerequisite: Graduate standing.
Seminars on current research topics in inorganic/analytical chemistry presented by faculty, visiting scholars, and postdoctoral and senior graduate students.
CHEM 271. Bioinorganic Chemistry
(3) BUTLER, FORD
Prerequisite: Chemistry 173A-B or the equivalent.
Selected topics in bioinorganic chemistry and metal-lobiochemistry with a major focus on recent developments. Topics will include discussions of metalloproteins and corresponding model compound investigations. Emphasis will be on reaction mechanisms and spectroscopic properties of metal sites.
CHEM 272. Raction Mechanisms in Organometallic and Inorganic Chemistry
(3) BUTLER, FORD
Prerequisite: Chemistry 173A-B, or equivalent.
Discussion of chemical reaction mechanisms. Emphasis will be on fundamentalreactions of metal compounds such as substitution, addition, elimination, and redox reactions for homogenous catalysis mechanisms and other complex systems.
CHEM 273. Structural Inorganic Chemistry
(3) STAFF
Prerequisite: Chemistry 173A-B, and 175; or equivalent.
The use of x-ray and neutron scattering to characterize solid state materials. Subjects include the crystal unit cell, space groups, structure determination and refinement. It is recommended that the student have an elementary introduction to vectors, matrices and fourier series.
CHEM 274. Solid State Inorganic/Materials
(3) STAFF
Prerequisite: Chemistry 173A-B or equivalent.
An introductory course describing the synthesis, physical characterization, structure, electronic properties and uses of solid state materials.
CHEM 275. Physical-Inorganic Chemistry
(3) FORD, WATTS, CHEETHAM
Prerequisite: Open only by consent of the chemistry graduate advisor.
Bonding theory, thermodynamics, and structure of inorganic compounds. Applications of physical techniques to the study of inorganic (and organometallic) reactions and their mechanisms.
CHEM 276. Photochemical and Photophysical Properties of Inorganic and Organometallic Compounds and Materials
(3) STAFF
Prerequisite: Chemistry 173A-B or equivalent.
Discussion of the mechanics of fundamental physical and chemical events which follow absorption of light by inorganic or organometallic chromophores. Consideration of homogeneous and heterogeneous systems as well as the design and operation of photo-optical and photoelectrical devices.
CHEM 277. Introduction to Inorganic Materials
(3) STAFF
Prerequisite: Chemistry 274.
Structures of inorganic materials: close-packing, linking of simple polyhedra. Factors that control structure: ionic radii, covalency, ligand field effects, metal-metal bonding, electron/ atom ratios. Structure-property relationships in e.g. spinels, garnets, perovskites, rutiles, flourites, zeolites, b-aluminas, graphites, common inorganic glasses.
CHEM 279. Selected Topics in Inorganic Chemistry
(1-4) STAFF
Prerequisite: Consent of instructor.
This course is designed to reflect recent developments in organic chemistry.
CHEM 281. Protein Crystallography
(3) STAFF
Prerequisite: Consent of instructor.
Introduction to diffraction techniques. protein crystal growth and morphology. Data collection and reduction strategies. Approaches for solving the phase problem. Crystallographic refinement, including molecular dynamics. Interpretation of crystal structures.
CHEM 282A. Synthesis and Bonding of Small Conjugated Molecules
(3) STAFF
Examination of small organic molecules used in optoelectronic devices: film transistors; light emitting diodes and solar cells. Methods for their synthesis. Influence of molecular structure on energies of molecular orbitals. Development of structure/function relationships based on solid state arrangements.
CHEM 282B. Organic Semiconductors for Energy Conversion
(3) STAFF
Basic photophysics of organic semiconductors. Examination of energy level alignments and solid state arrangements required for the conversion of solar energy into useful electrical energy. Important device considerations for evaluating power conversion efficiencies. Comparison of different solar conversion technologies.
CHEM 282C. Instrumental Methods in Materials Chemistry
(3) NGUYEN, BURATTO, SESHADRI
Prerequisite: Chemistry 109A-B-C and Physics 6A-B-C
Principles and practice of advanced research instrumentation for soft materials characterization including spectroscopy, microscopy, and X-ray techniques
CHEM 284. Chemical Literature
(2) HUBER
Prerequisite: Consent of the chemistry graduate adviser only.
Lectures and exercises on the literature and other information resources of use in chemistry.
CHEM 285. Synthetic Chemistry of Macromolecules
(3) STAFF
Prerequisite: Consent of instructor.
Molecular architecture and classifica tion of macromolecules. Different methods for the preparation of polymers: free radical polymerization, ionicpolymerization, condensation polymerization and coordination polymerization. bulk, solution, and emulsion polymerization. Principles of copolymerization, blockcopolymerization, grafting, network formation, chemical reactions on polymers.
CHEM 290. Seminar in Chemistry and Biochemistry
(2) STAFF
Prerequisite: Consent of instructor.
Presentation of seminar required of all departmental graduate students.
CHEM 293. Faculty Research Seminar
(2) STAFF
Prerequisite: Consent of instructor.
A series of seminars by departmental faculty describ ing their active research projects.
CHEM 501A. Techniques of Teaching and Laboratory Class Supervision
(2) STAFF
Prerequisite: Graduate standing.
An initial two-thre day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants.
CHEM 501B. Techniques of Teaching and Laboratory Class Supervision
(2) STAFF
Prerequisite: Graduate standing.
An initial two-thre day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants.
CHEM 595. Group Studies
(2) STAFF
Critical review of research in selected fields. Regular meetings are held in which the student presents for discussion information from the recent chemical literature.
CHEM 596. Directed Reading and Research
(2-12) STAFF
Individual tutorial. Instructor is usually the student's major research advisor. Each faculty member has a unique number designation.
CHEM 597. Individual Study for Master's Comprehensive Examinations and Ph.D. Examinations.
(1-3) STAFF
Instructor should be the student's major professor or chairman of the doctoral committee.
CHEM 598. Master's Thesis Research and Preparation
(1-12) STAFF
Only for research underlying the thesis, writing the thesis. Instructor should be the chairman of the student's thesis committee.
CHEM 599. Ph.D. Dissertation Research and Preparation
(1-12) STAFF
Only for research underlying the dissertation, writing the dissertation. Instructor should be the chair of the student's doctoral committee.