ARCHIVED CATALOG: Visit catalog.ucsb.edu to view the 2023-2024 General Catalog.

UC Santa Barbara General CatalogUniversity of California, Santa Barbara

Chemistry and Biochemistry

Division of Mathematical, Life, and Physical Sciences
Building 232
Telephone (805) 893-5675
Undergraduate e-mail: ugrads@chem.ucsb.edu
Graduate e-mail: gradprog@chem.ucsb.edu
Website: www.chem.ucsb.edu  
Department Chair: Mattanjah S. de Vries


 

Some courses displayed may not be offered every year. For actual course offerings by quarter, please consult the Quarterly Class Search or GOLD (for current students). To see the historical record of when a particular course has been taught in the past, please visit the Course Enrollment Histories.

Chemistry and Biochemistry
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Collapse Courses Lower Division 
CHEM 1A. General Chemistry
(3) STAFF
Recommended Preparation: Concurrent enrollment in Chemistry 1AL. High school algebra, chemistry, and physics.
Enrollment Comments: Not open for credit to students who have completed Chemistry 2A.
The atomic structure of matter; atoms, ions, and chemical compounds; balancing equations and reaction stoichiometry; composition of aqueous solutions and solution stoichiometry; gases; quantum chemistry and the electronic structure of atoms; introduction to chemical bonding; molecular shape and electronic structure of molecules
CHEM 1AL. General Chemistry Laboratory
(2) STAFF
Prerequisite: Chemistry 1A or 2A (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 1AC or 2AC. Lab fee required.
Qualitative and quantitative measurements to develop laboratory technique and demonstrate the basic concepts of stoichiometry, chemical bonding, gas laws, chemical equilibrium, and acid-base chemistry.
CHEM 1B. General Chemistry
(3) STAFF
Prerequisite: Chemistry 1A or 2A with a minimum grade of C-.
Recommended Preparation: Chemistry 1 AL or 2AC, and concurrent enrollment in Chemistry 1BL. High school algebra, chemistry, and physics.
Enrollment Comments: Not open for credit to students who have completed Chemistry 2B.
Thermochemistry; spontaneous processes and the second law of thermodynamics; chemical kinetics; equilibrium; acids and bases; equilibrium processes in aqueous solutions; electrochemistry
CHEM 1BL. General Chemistry Laboratory
(2) STAFF
Prerequisite: Chemistry 1A or 2A with a minimum grade of C-; Chemistry 1B or 2B (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 1BC or 2BC.
Qualitative and quantitative measurements to develop laboratory technique and demonstrate basic concepts of thermochemistry, electrochemistry, chemical kinetics and atomic spectroscopy.
CHEM 1C. General Chemistry
(3) STAFF
Prerequisite: Chemistry 1B or 2B with a minimum grade of C-.
Recommended Preparation: Chemistry 1BL or 2BC, and concurrent enrollment in Chemistry 1CL. High school algebra, chemistry, and physics.
Enrollment Comments: Not open for credit to students who have completed Chemistry 2C.
Liquids and Intermolecular forces; properties of solutions; transition elements and coordination complexes; organic chemistry and synthetic polymers; natural polymers; nuclear chemistry.
CHEM 1CL. General Chemistry Laboratory
(2) STAFF
Prerequisite: Chemistry 1B or 2B with a minimum grade of C-; Chemistry 1C or 2C (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 1CC or 2CC.
Qualitative and quantitative measurements to develop laboratory technique and demonstrate the basic concepts of solutions, intermolecular forces, colligative properties, and synthetic organic inorganic chemistry.
CHEM 2A. General Chemistry (Honors)
(3) STAFF
Recommended Preparation: Concurrent enrollment in Chemistry 2AC; high school algebra, chemistry and physics, and one quarter of calculus (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 1A.
The sequence of topics will be similar to that in Chemistry 1A. Calculus will be used as needed, at the level of the concurrent Mathematics 3A course.
CHEM 2AC. General Chemistry Laboratory (Honors)
(2) STAFF
Prerequisite: Chemistry 2A (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 1AL or 1AC.
Qualitative and quantitative measurements to develop laboratory technique and demonstate the basic concepts of stoichiometry, chemical bonding, gas laws, chemical equilibrium, and acid-base chemistry. Students work in small groups to develop a unique perspective on the experiment.
CHEM 2B. General Chemistry (Honors)
(3) STAFF
Prerequisite: Chemistry 2A or 1A with a minimum grade of B.
Recommended Preparation: Chemistry 2AC or 1AL with a minimum grade of B; concurrent enrollment in Chemistry 2BC. High school algebra, chemistry, and physics, and one quarter of calculus.
Enrollment Comments: Not open for credit to students who have completed Chemistry 1B.
Thermodynamics (first and second law), electrochemistry, chemical kinetics, atomic and molecular structure, and chemical bonding.
CHEM 2BC. General Chemistry Laboratory (Honors)
(2) STAFF
Prerequisite: Chemistry 2A or 1A with a minimum grade of B; Chemistry 2AC or 1AL with a minimum grade of B; and Chemistry 2B (may be taken concurrently).
Enrollment Comments: Quarters usually offered: Winter. Not open for credit to students who have taken Chemistry 1BC or 1BL.
Repeat Comments: Not open for credit to students who have taken Chemistry 1BC or 1BL.
Laboratory techniques. Thermochemistry, electrochemistry, chemical kinetics, and atomic spectroscopy. Students work in small groups to develop a unique perspective on the experiment.
CHEM 2C. General Chemistry (Honors)
(3) STAFF
Prerequisite: Chemistry 2B or 1B with a minimum grade of B.
Recommended Preparation: Chemistry 2BC or 1BL with a minimum grade of B; concurrent enrollment in Chemistry 2CC. High school algebra, chemistry, and physics, and one quarter of calculus.
Enrollment Comments: Not open for credit to students who have taken Chemistry 1C.
Structure and dynamics of the elements and their compounds. Aspects of technology and environmental problems.
CHEM 2CC. General Chemistry Laboratory (Honors)
(2) STAFF
Prerequisite: Chemistry 2B or 1B with a minimum grade of B; and Chemistry 2BC or 1BL with a minimum grade of B; and Chemistry 2C (may be taken concurrently).
Enrollment Comments: Quarters usually offered: Spring. Not open for credit to students who have taken Chemistry 1CC or 1CL.
Repeat Comments: Not open for credit to students who have taken Chemistry 1CC or 1CL.
Laboratory techniques. Solutions, colligative properties, and synthetic organic and inorganic chemistry. Students work in small groups to develop a unique perspective on the experiment.
CHEM 6AL. Laboratory Methods of Organic Chemistry
(3) STAFF
Prerequisite: Chemistry 1AL or 2AC, 1BL or 2BC, and 1CL or 2CC; 109A or 109AH with a minimum grade of a C-; and Chemistry 109B or 109BH (may be taken concurrently).
Distillation, crystallization, extraction, determination of physical properties, spectroscopy, and instrumental methods in organic chemistry.
CHEM 6BH. Laboratory Methods of Organic Chemistry (Independent Research)
(3) STAFF
Prerequisite: Chemistry 6AL and 109A or 109AH; and Chemistry 109B or 109BH (may be taken concurrently); open to chemistry, biochemistry and creative studies majors only; consent of instructor.
Enrollment Comments: Quarters usually offered: Winter, Spring.
Independent research involving distillation, crystallization, extraction, determination of physical properties, organic synthesis, and use of instrumental methods in organic chemistry.
CHEM 6BL. Laboratory Methods of Organic Chemistry
(3) STAFF
Prerequisite: Chemistry 6AL and 109A or 109AH with a minimum grade of C-; and Chemistry 109B or 109BH.
Distillation, crystallization, extraction, determination of physical properties, organic synthesis, instrumental methods in organic chemistry.
CHEM 6CH. Organic Chemistry Labs
(3) STAFF
Prerequisite: Chemistry 6BL or 6BH and 109B or 109BH; and Chemistry 109C or CHEM 109CH (may be taken concurrently); open to chemistry, biochemistry and creative studies majors only; consent of instructor.
Enrollment Comments: Quarters usually offered: Winter, Spring. Not open for credit to students who have completed Chemistry 7C. Lab fee required.
Independent research involving distillation, crystallization, extraction, determination of physical properties, organic synthesis, and use of instrumental methods in organic chemistry for the purposes of multistep synthesis.
CHEM 6CL. Organic Chemistry Labs
(3) STAFF
Prerequisite: Chemistry 6BL or 6BH and 109B or 109BH with a minimum grade of C-; and Chemistry 109C or 109CH (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 7C. Lab fee required.
Distillation, crystallization, extraction, determination of physical properties, organic synthesis, instrumental methods in organic chemistry.
CHEM 25. Introductory Chemistry
(3) STAFF
Prerequisite: Not open to students who have completed Natural Science 1B or Chemistry 1A or Chemistry 2A. Cannot be taken concurrently with Chemistry 1A or Chemistry 2A.
Enrollment Comments: Designed as a preparatory course for Chemistry 1A. Intended for students with limited or no high school chemistry background, and/or students who received an SAT Math Score of 550 or below.
Includes fundamental topics, such as matter, measurements, atomic/electronic structure, atomic theories, bonding, reactions, and stoichiometry.
CHEM 99. Introduction to Research
(1-3) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: May be repeated to a maximum of 6 units. Students are limited to 5 units per quarter and 30 units total in all 98/99/198/199/199AA-ZZ courses combined.
Directed study, normally experimental, to be arranged with individual faculty members. Course offers exceptional students an opportunity to participate in a research group. Basic techniques and the operation of instruments used in research. A few students in chemistry are quite advanced having had extensive laboratory training in high school or elsewhere. This course allows them the opportunity to participate in a research group before they acquire 84 units and are then eligible for and capable of handling 199, Independent Studies.
Collapse Courses Upper Division 
CHEM 102. Teaching Chemistry at the High School/Junior High Level
(4) STAFF
Prerequisite: Chemistry 1A-AL, 1B-BL, 1C-CL
Enrollment Comments: Open to non-majors. Upper Division course credit toward Science and Mathematics Education minor. Will not count towards the Biochemistry, Chemistry BA or Chemistry BS major requirements.
Students will work to develop a high school/junior high curriculum unit. In addition, students will work in either a high school or junior high classroom and share their experiences through class discussions. Students will also have the opportunity to participate in one of two elementary outreach programs that are run out of the chemistry department.
CHEM 104. The Science and Engineering of Energy Conversion
(3) MCFARLAND
Prerequisite: Chemical Engineering 110A and 140A; or consent of instructor
Enrollment Comments: Equivalent upper-division coursework in thermodynamics and kinetics from outside of the department will be considered. Same course as CH E 141.
Framework for understanding the energy supply issues facing society with a focus on the science, engineering, and economic principles of the major alternatives. Emphasis is on the physical and chemical fundamentals of energy conversion technologies.
CHEM 109A. Organic Chemistry
(4) STAFF
Prerequisite: Chemistry 1C or 2C with a minimum grade of C-; or Chemistry 1B or 2B with a minimum grade of B-.
Enrollment Comments: Not open for credit to students who have completed Chemistry 107A or 130A or 109AH.
Structure, reactivity and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acids, proteins, nucleic acids, coenzymes and their mechanisms.
CHEM 109AH. Organic Chemistry (H)
(4) STAFF
Prerequisite: Chemistry 1B/2B or 1C/2C with a minimum grade of B.
Recommended Preparation: Chemistry 6AL (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 109A or 130A.
Structure, nomenclature, stereochemistry, and reactivity of organic molecules. Suitable for undergraduates requiring strong understanding of organic chemistry and possessing strong background in science, such as honors students, majors in chemistry, biochemistry-chem, chemical engineering, etc. This course cannot be repeated.
CHEM 109B. Organic Chemistry
(4) STAFF
Prerequisite: Chemistry 109A or 109AH with a minimum grade of C-.
Enrollment Comments: Not open for credit to students who have completed Chemistry 107B or 130B or 109BH.
Structure, reactivity and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acides, proteins, nucleic acids, coenzymes and their mechanisms.
CHEM 109BH. Organic Chemistry (H)
(4) STAFF
Prerequisite: Chemistry 109A with a minimum grade of B+ or Chemistry 109AH with a minimum grade of B.
Recommended Preparation: Chemistry 6BL (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 109B or 130B.
Structure, nomenclature, stereochemistry, and reactivity of organic molecules. Suitable for undergraduates requiring strong understanding of organic chemistry and possessing strong background in science, such as honors students, majors in chemistry, biochemistry-chem, chemical engineering, etc. This course cannot be repeated.
CHEM 109C. Organic Chemistry
(4) STAFF
Prerequisite: Chemistry 109B or 109BH with a minimum grade of C-.
Enrollment Comments: Not open for credit to students who have completed CHEM 107C or CHEM 109CH or CHEM W 109C. These courses also may not be taken concurrently.
Repeat Comments: CHEM 109C is a legal repeat of CHEM W 109C (which is the online version of CHEM 109C).
Structure, reactivity and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acides, proteins, nucleic acids, coenzymes and their mechanisms.
CHEM 109CH. Organic Chemistry (H)
(4) STAFF
Prerequisite: Chemistry 109B with a minimum grade of B+ or Chemistry 109BH with a minimum grade of B.
Recommended Preparation: Chemistry 6CL (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 109C or 130C.
Structure, reactivity, mechanisms, synthesis, nomenclature, and spectroscopic identification of the principal classes of organic compounds as well as organometallics, amino acids, proteins, and carbohydrates. This course is intended for chemistry majors and others requiring a strong basis in organic chemistry.
CHEM 110. Introduction to the Chemical Applications of Group Theory
(3) LAVERMAN L E
Prerequisite: Chem 1A, 1B, or 2A, 2B.  Concurrent enrollment in Chem 1C or 2C.
Enrollment Comments: Designed for majors. Same course as Chem CS 110. Not open for credit to students who have completed Chem CS 110. Any major outside the Department of Chemistry & Biochemistry will need instructor approval.
The mathematics of group theory is introduced. Point groups and symmetryoperations will be applied toward the normal coordinate analysis of molecular vibrations and the construction of molecular orbitals from symmetry adapted linear combinations of atomic orbitals.
CHEM 110L. Introductory Biochemistry Laboratory
(4) STAFF
Prerequisite: Chemistry 142A or Chemistry W 142A (may be taken concurrently).
Recommended Preparation: Chemistry 6AL-BL; and Chemistry 107A-B-C or 109A or 109AH-109B or 109BH-109C or 109CH.
Enrollment Comments: Designed for majors. Quarters usually offered: Fall. Lab fee required.
Gives students hands-on experience with modern methods of separation, identification, and study of biomolecules and macromolecular structures. Focus is on techniques but the course also gives an introduction to computer-based bioinformatics tools.
CHEM 111. Chemical Kinetics
(3) STAFF
Prerequisite: Consent of instructor.
The laws and theories governing rates of chemical reactions and reaction mechanisms. Empirical treatment of reaction rates, treatment of data, gas-phase reactions, reactions in solution, catalysis, complex reactions, chain reactions. Collision theory and potential energy surfaces.
CHEM 112A. Biophysical Chemistry
(4) STAFF
Prerequisite: Chemistry 1C or 2C; and, Mathematics 2A-B or 3A-B, 4A or 3C, and 6A or 5A; and, Physics 1, 2, 3, 3L, 4, and 4L, or, Physics 6A-AL-B-BL-C-CL; Chemistry 142A, Chem W 142A or MCDB 108A (may be taken concurrently).
Repeat Comments: Illegal Repeat of CHEM 113A
Laws of thermodynamics, chemical equilibria and ligand binding, phase equilibria, electrochemistry, nonelectrolyte solutions, applications to biochemical problems.
CHEM 112B. Biophysical Chemistry
(4) STAFF
Prerequisite: Chemistry 112A; Chemistry 142A or Chemistry W 142A or MCDB 108A; Chemistry 142B or MCDB 108B (may be taken concurrently).
Enrollment Comments: Quarters usually offered: Winter. Not open to students who have completed Chemistry 113B
Repeat Comments: Illegal Repeat of Chemistry 113B.
Forces influencing macromolecular conformation, microscopy and diffraction methods, quantum mechanics, statistical mechanics.
CHEM 112C. Biophysical Chemistry
(4) STAFF
Prerequisite: Chemistry 112B; Chemistry 142B or MCDB 108B; Chemistry 142C or MCDB 108C (may be taken concurrently).
Enrollment Comments: Quarters usually offered: Spring. Not open to students who have completed Chemistry 113C.
Repeat Comments: Illegal Repeat of Chemistry 113C.
Biological spectroscopy, nuclear magnetic resonance, mass transport dynamics in solution, chemical and biochemical kinetics.
CHEM 112L. Biophysical and Bioanalytical Laboratory
(3) STAFF
Prerequisite: Chemistry 125L and Chemistry 142C (may be taken concurrently).
Recommended Preparation: Chemistry 112A-B-C
Enrollment Comments: Designed for majors. Quarters usually offered: Spring. Lab fee required.
Application of modern biophysical and bioanalytical techniques to study the structure, function, and properties of biomolecules. Fluorescence spectroscopy, mass spectroscopy, FTIR, 2D-NMR, diffraction techniques, circular dichroism.
CHEM 113A. Physical Chemistry
(4) STAFF
Prerequisite: Chemistry 1C or 2C; and, Mathematics 2A-B or 3A-B, 4A or 3C, and 6A or 5A; and, Physics 1-2-3-3L-4-4L, or, Physics 6A-AL-B-BL-C-CL.
Enrollment Comments: Quarters usually offered: Fall. Not open to students who have completed Chemistry 112A.
Repeat Comments: Illegal Repeat of CHEM 112A.
Chemical thermodynamics: laws of thermodynamics, phase equilibria, chemical equilibria, equations of state.
CHEM 113AL. Physical Chemistry Laboratory
(3) WODTKE
Prerequisite: Chemistry 113A (may be taken concurrently).
Recommended Preparation: Chemistry 150 or equivalent.
Lecture: instrumental techniques, data analysis, error analysis, instruction in Mathematica-R. Laboratory: Mathematica-R, a symbolic programming language, is taught in the computer laboratory.
CHEM 113B. Physical Chemistry
(4) STAFF
Prerequisite: Chemistry 113A or Chemical Engineering 110A-B.
Recommended Preparation: Chemistry 150 and 116AL (may be taken concurrently), Math 4B.
Enrollment Comments: Quarters usually offered: Winter. Not open to students who have completed Chemistry 112B.
Repeat Comments: Illegal Repeat of CHEM 112B
Quantum theory and spectroscopy: introduction to quantum mechanics; symmetry, molecular structure, and spectroscopy.
CHEM 113C. Physical Chemistry
(4) STAFF
Prerequisite: Chemistry 113B.
Enrollment Comments: Quarters usually offered: Spring. Not open to students who have completed Chemistry 112C.
Repeat Comments: Illegal Repeat of CHEM 112C.
Kinetic theory of gases, chemical kinetics, statistical mechanics, photochemistry.
CHEM 115A. Fundamentals of Quantum Chemistry
(3) STAFF
Prerequisite: Mathematics 4B, and Chemistry 113A-B-C or Chemistry 112A-B-C.
Enrollment Comments: Offered concurrently with Chemistry 222A-B-C.
Introduction to quantum mechanics-postulatory approach; particle in box, on ring, harmonic oscillator; linear operator theory, matrix algebra; hydrogen atom; perturbation theory, variation theory; applications.
CHEM 115B. Fundamentals of Quantum Chemistry
(3) STAFF
Prerequisite: Chemistry 113A-B-C or Chemistry 112A-B-C, Mathematics 5A.
Enrollment Comments: Offered concurrently with Chemistry 222B.
Molecular orbital theory and valence bond theory; Huckel theory (secular eqn.) applications to conjugated systems, electronic spectra, and term symbols; introduction to infrared, Raman, and microwave spectroscopy.
CHEM 115C. Fundamentals of Quantum Chemistry
(3) STAFF
Prerequisite: Chemistry 113A-B-C or Chemistry 112A-B-C, Mathematics 5A.
Enrollment Comments: Offered concurrently with Chemistry 222C.
Introduction to NMR, EPR, group theory; and applications.
CHEM 116AL. Quantitative Analytical and Physical Methods Laboratory
(3) STAFF
Prerequisite: Chemistry 150; Chemistry 113B (may be taken concurrently).
Enrollment Comments: Designed for majors. Quarters usually offered: Winter. Lab fee required.
Principles of analytical chemistry including spectroscopy, classical techniques and separation processes. Quantitative analysis of unknowns. Introduction to instrumental analysis.
CHEM 116BL. Advanced Physical Chemistry Laboratory
(3) STAFF
Prerequisite: Chemistry 116AL; Chemistry 113C (may be taken concurrently).
Enrollment Comments: Designed for majors. Quarters usually offered: Spring. Lab fee required.
Experiments in thermodynamics, spectroscopy, and electrochemistry. Synthesis and study of inorganic complexes. Instrumental techniques such as NMR, fluorescence, Raman and laser flash photolysis are explored. Methods of data and error analysis.
CHEM 116CL. Inorganic Synthesis and Physical Characterization Laboratory
(3) STAFF
Prerequisite: Chemistry 113C and 116BL; Chemistry 173A (may be taken concurrently).
Enrollment Comments: Designed for majors. Quarters usually offered: Fall. Lab fee required.
Synthesis of inorganic and organometallic complexes including techniques for air-sensitive materials. Instrumental characterization and study of synthesized compounds in a research-like setting.
CHEM 117A. Statistical Mechanics
(3) BROWN, METIU, SHEA
Prerequisite: Chemistry 113A-B-C or Chemistry 112A-B-C.
Fundamentals of statistical thermodynamics, partition functions for ideal gases and crystals, quantum statistics, calculations of thermodynamic properties.
CHEM 118. Photochemistry and Radiation Chemistry
(3) BURATTO
Prerequisite: Chemistry 113A-B-C or Chemistry 112A-B-C; and 150.
Interaction of light and matter, reaction paths from electronically excited molecules, flash photolysis, high energy radiation.
CHEM 123. Fundamentals of Environmental Chemistry
(3) DE VRIES, PERONA
Prerequisite: Chemistry 1A-B.
Recommended Preparation: Chemistry 1C.
Study of Earth's biogeochemical cycles with respect to carbon, nitrogen, and sulfur. Introduction to the science of climate change, including effects of global warming on terrestrial and aquatic ecosystems. Environmental impacts of fossil fuel and biofuel technologies. Chemistry of the atmosphere, hydrosphere, and lithosphere, with emphasis on ozone depletion, photochemical smog, acid rain, global ocean acidification, soil and groundwater contamination, and environmental costs of industrialized agriculture.
CHEM 124. Organic Spectroscopic Analysis
(3) STAFF
Prerequisite: Chemistry 107A-B or 109A-B; and Chemistry 6A.
Recommended Preparation: Chemistry 107C or 109C.
Structure determination of complex organic molecules. Topics covered include NMR, IR, UV, and mass spectrometry.
CHEM 125L. Laboratory Techniques in Biochemistry
(4) STAFF
Prerequisite: Chemistry 110L; and Chemistry 142A or Chemistry W 142A; and Chemistry 142B (may be taken concurrently).
Recommended Preparation: Chemistry 109A or 109AH-109B or 109BH-109C or 109CH; and Chemistry 6AL-BL.
Enrollment Comments: Designed for majors. Quarters usually offered: Winter. Lab fee required.
Application of molecular biology techniques to perform mutagenesis and cloning; restriction endonucleases, PCR, plasmid purification and DNA analysis. Protein purification and analysis methods: expression of proteins in bacterial systems.
CHEM 126. Computation Chemistry and Molecular Modeling
(3) AUE, GERIG
Prerequisite: Chemistry 109A-B.
Recommended Preparation: Chemistry 107C or 109C.
Enrollment Comments: Same course as EEMB 126MM.
Introduction to computational chemistry and molecular modeling. Application of molecular mechanics, quantum mechanics and computer graphical interfaces to problems in chemistry, biochemistry, drug design and pharmacology.
CHEM 127. Structure and Reactivity in Organic Chemistry
(3) STAFF
Prerequisite: Chemistry 107A-B-C or 109A-B-C with a C or better.
Electronic structure, resonance, acid/base chemistry, thermodynamics, kinetics, transition state theory, and isotope effects.
CHEM 128. Organic Reaction Mechanisms
(3) STAFF
Prerequisite: Chemistry 107A-B-C or 109A-B-C.
Recommended Preparation: Chemistry 127.
Mechanisms of thermal, photochemical, organometallic, electrochemical asymmetric or other processes in organic chemistry.
CHEM 129. Synthetic Organic Reactions
(3) STAFF
Prerequisite: Chemistry 107A-B-C or 109A-B-C.
A survey of reactions of organic substances with emphasis on those with practical synthetic utility, including discussion of mechanism, scope and limitations, and steriochemical issues.
CHEM 130A. Organic Chemistry
(4) STAFF
Prerequisite: Chemistry 1C or 2C.
Recommended Preparation: Chemistry 6A (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 107A.
Structure, reactivity, mechanisms, synthesis, nomenclature, and spectroscopic identification of the principle classes of organic compounds as well as organometallics, amino acids, proteins, and carbohydrates. This course is intended for chemistry majors and others requiring a strong basis in organic chemistry.
CHEM 130B. Organic Chemistry
(4) ANDERSON, AUE, LIPSHUTZ, LITTL
Prerequisite: Chemistry 130A.
Recommended Preparation: Chemistry 6B or 7B (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 107B.
Structure, reactivity, mechanisms, synthesis, nomenclature, and spectroscopic identification of the principal classes of organic compounds as well as organometallics, amino acids, proteins, and carbohydrates. This course is intended for chemistry majors and others requiring a strong basis in organic chemistry (see majors in biochemistry-molecular biology, chemical engineering, pharmacology, physiology, and cell biology).
CHEM 130C. Organic Chemistry
(4) ANDERSON, AUE, LIPSHUTZ
Prerequisite: Chemistry 130B.
Recommended Preparation: Chemistry 6C and 7C (may be taken concurrently).
Enrollment Comments: Not open for credit to students who have completed Chemistry 108.
Structure, reactivity, mechanisms, synthesis, nomenclature, and spectroscopic identification of the principal classes of organic compounds as well as organometallics, amino acids, proteins, and carbohydrates. This course is intended for chemistry majors and others requiring a strong basis in organic chemistry.
CHEM 132. Organometallics in Organic Synthesis
(3) STAFF
Prerequisite: Chemistry 109A-B-C and Chemistry 129; upper-division standing.
Enrollment Comments: Designed for majors. Quarters usually offered: Spring.
Synthetic methods and applications to natural products total syntheses involving transition metals.
CHEM 133. Advanced Synthetic Chemistry
(3) STAFF
Prerequisite: Chemistry 109A-B-C; upper-division standing; open to chemistry and biochemistry majors only.
Recommended Preparation: Taken or concurrently enrolled in Chem 129.
Enrollment Comments: Designed for majors. Quarters usually offered: Spring.
A comprehensive discussion of modern synthetic organic methods, including the applications of addition, condensation, substitution, and rearrangement reactions for building complicated molecules from scratch.
CHEM 134. Chemical Synthesis of Biological Molecules
(3) STAFF
Prerequisite: Chemistry 129; upper-division standing.
Enrollment Comments: Quarters usually offered: Spring.
The synthesis, manipulation, and modification of biological molecules including peptides, carbohydrates, nucleic acids, and other metabolites are essential to advances in biomedicine. This course surveys chemical methods for the production of these molecules and their application to biological problems.
CHEM 141. Epigenetics: Biology, Mechanisms and Therapies
(3) STAFF
Prerequisite: Chemistry W142A or 142A, 142B-C; or, MCDB 108A-B-C; upper-division standing.
Covers epigenetic processes and molecular mechanisms in bacteria, fungi, plants, mammals, imprinting, gene regulation, repeat-induced point mutation (RIP), X- chromosome inactivation, epigenetic mechanisms including DNA methylation, histone modification, chromatin remodeling, RNA silencing, and epigentically based therapeutics and pharmaco-epigenetics.
CHEM 142A. Biochemistry
(3) STAFF
Prerequisite: Chemistry 107A-B-C or 109A or 109AH-109B or 109BH-109C or 109CH or W 109C
Macromolecules of biological importance. A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of biomolecules.
CHEM 142AH. Biochemistry-Honors Discussion
(1) REICH
Prerequisite: Concurrent enrollment in Chem 142A.
Discussion sections using science articles to convey how science gets done and its limitations. Students learn how to read science papers, the publication process, resources for finding papers and how to dissect them into experiments and conclusions. Students attend research seminars and group meetings involving presentations by Chemistry & Biochemistry graduate students.
CHEM 142B. Biochemistry
(3) STAFF
Prerequisite: Chem 142A or Chem W 142A.
Enrollment Comments: Quarters usually offered: Winter.
Chemical aspects of intermediary metabolism. The chemistry and elementary dynamic properties of enzymes; study of enzyme active sites; characterization of metabolic pathways and methods of examining cellular regulation.
CHEM 142BH. Biochemistry-Honors Discussion
(1) REICH
Prerequisite: Concurrent enrollment in Chem 142B.
Discussion sections using science articles to convey how science gets done and its limitations. Students learn how to read science papers, the publication process, resources for finding papers and how to dissect them into experiments and conclusions. Students will attend research seminars and group meetings involving presentations by Chemistry & Biochemistry graduate students.
CHEM 142C. Biochemistry
(3) STAFF
Prerequisite: Chemistry 142B.
Enrollment Comments: Quarters usually offered: Spring.
Macromolecular biosynthesis and specialized cellular processes. A survey of nucleic acid and protein biosynthesis, characterization of lipids and membranes; function of membranes in transport, energy transduction, and cellular control; mechanisms of muscle contraction and cell motility.
CHEM 142CH. Biochemistry-Honors Discussion
(1) REICH
Prerequisite: Concurrent enrollment in Chem 142C.
Discussion sections using science articles to convey how science gets done and its limitations. Students learn how to read science papers, the publication process, resources for finding papers and how to dissect them into experiments and conclusions. Students will attend research seminars and group meetings involving presentations by Chemistry & Biochemistry graduate students.
CHEM 143. The RNA World
(3) STAFF
Prerequisite: Chemistry W142A or 142A, 142B-C; or, MCDB 108A-B-C.
Introduction to RNA structure and thermodynamics. Biological roles of RNA in contemporary organisms. Implications for the origins of life.
CHEM 145. Computational Biochemistry
(3) STAFF
Prerequisite: Chemistry 113A-B or Chemistry 112A-B; and, Chemistry 142A or Chem W142A or MCDB 108A.
Enrollment Comments: Offered concurrently with Chemistry 245 and BMB 245.
Introduction to molecular modeling and molecular dynamics. Discussion of practical considerations of energy minimization, solvent modeling, structure-based drug design. Practical computer graphics experience.
CHEM 146. Membrane Biochemistry
(3) STAFF
Prerequisite: Chem 142A or Chem W142A or MCDB 108A; Chemistry 142B or MCDB 108B (may be taken concurrently).
Enrollment Comments: Concurrently offered with Chemistry 246.
Introduction to the structures and roles of lipids and their phase behavior, liposomes, membrane proteins and kinetics, protein sorting, and signal transduction.
CHEM 147. Astrobiology and the Origins of Life
(3) STAFF
Prerequisite: Chemistry 142A or Chem W142A or MCDB 108A.
Discusses the origins and evolution of the solar system and the earth, the origins and evolution of life on earth, and the possibilities for life elsewhere in the cosmos, all from the perspective of contemporary, terrain biochemistry.
CHEM 148. Introduction to Nucleic Acid Nanotechnology and Synthetic Biology
(3) STAFF
Prerequisite: Chemistry 142A or Chemistry W 142A, and Chemistry 142B; or MCDB 108A or MCDB W 108A and MCDB 108B
This integrative, interdisciplinary course introduces Nucleic Acid Nanotechnology and Synthetic Biology from molecular, biochemical, biophysical and evolutionary perspectives. Recent developments aiming at engineering new biomaterials, therapeutics, nano-machines, nano-robots, alternative genetic and regulatory systems and new cellular organisms will be presented.
CHEM 149. How Science Works
(3) STAFF
Prerequisite: Chemistry 1A-1B-1C or 2A-2B-2C
Enrollment Comments: Open to non-majors. This course requires attendance/participation in a lab once (three to four hours) during three different weeks of the quarter.
Combined lab and discussion course on how science works. Includes three labs on student-generated questions. Discussions include the analysis of research papers, science controversies, how science defines new areas of ?ignorance,? and the observation of research group meetings.
CHEM 150. Analytical Chemistry
(3) BURATTO, STROUSE
Prerequisite: Chemistry 1A-B-C or 2A-B-C.
Recommended Preparation: Chemistry 116AL (may be taken concurrently).
Principles of analytical chemistry including classical techniques, spectrophotochemistry, electroanalytical techniques, and separation processes.
CHEM 151. Post-translational Protein Processing
(4) STAFF
Prerequisite: MCDB 108A or Chemistry 142A with a grade of C or better.
Enrollment Comments: Same course as MCDB 145.
Structure/function relationships in interesting macromolecules isolated from marine organisms. Focus is on well-characterized pathways from horseshoe crabs, abolones, mussels, and fish as well as others.
CHEM 153. Advanced Analytical Techniques
(3) STROUSE
Prerequisite: Chemistry 150.
Principles of analytical methodology, as in spectroscopy, electroanalysis, and chromatography. Applications to environmental problems, forensic and clinical analysis, and industry. Analysis of solids and surfaces.
CHEM 154A. Magnetic Resonance in Biological Systems
(3) STAFF
Prerequisite: Chemistry 113A-B or Chemistry 112A-B-C
A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.
CHEM 154B. Magnetic Resonance in Biological Systems
(3) STAFF
Prerequisite: Chemistry 113A-B or Chemistry 112A-B; and, Chemistry 112C or 113C (may be taken concurrently).
A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.
CHEM 161. Enzyme Mechanisms
(3) STAFF
Prerequisite: Chemistry 142A or W142A, 142B-C; or, MCDB 108A-B-C.
Chemistry, structure and function of enzymes; theory, experimental design, and data analysis. Enzyme models and non-classical enzymes.
CHEM 162A. Drug Design
(3) STAFF
Prerequisite: Chemistry 142A or W142A, 142B-C; or, MCDB 108A-B-C.
Recommended Preparation: MCDB 101A-B, Chemistry 126, 145, or 161.
Sources for new drugs. Biochemistry of diseases. Target validation techniques. Mechanism of action of enzymes and receptors. Enzyme inhibition and receptor binding studies. Structure based drug design: conformational analysis, docking and binding affinity calculations. Course also teaches proposal writing skills.
CHEM 162B. Drug Design
(3) STAFF
Prerequisite: Chemistry 142A or W142A, 142B-C; or, MCDB 108A-B-C.
Recommended Preparation: Chemistry 127, 129, or 162A.
Medical chemistry for lead optimization, combinatorial synthesis, quantitative structure-activity relationships, pharmocokinetics, drug metabolism and toxicity, pharmacogenomics. Drugs that interact with DNA and protein drugs. Clinical trials, intellectual property in drug design. Students develop their own drug design project.
CHEM 163. Arrow Pushing in Organic Chemistry
(3) STAFF
Prerequisite: Chemistry 109A-B-C; upper-division standing; open to chemistry and biochemistry majors only.
Recommended Preparation: Taken or concurrently enrolled in one of the following; Chemistry 127, 128, 129, or 133.
Enrollment Comments: Designed for majors. Quarters usually offered: Fall.
Covers the arrow pushing formalism and addresses organic reactions from this perspective.
CHEM 171. Bioinorganic Chemistry
(3) BUTLER
Prerequisite: Chemistry 173A.
Selected topics in bioinorganic chemistry, and metallo-biochemistry. Discussions of metalloproteins and corresponding model compound investigations. Emphasis will be on reaction mechanisms and spectroscopy or properties of metal sites.
CHEM 173A. Advanced Inorganic Chemistry
(3) STAFF
Prerequisite: Chemistry 113A-B-C, or Chemistry 112A-B-C.
Enrollment Comments: Concurrently offered with Chemistry 268A. Quarters usually offered: Summer, Fall.
Electronic structure of atoms and molecules. Models for bonding in molecules of nontransition and transition elements. Applications of symmetry to bonding, electronic and vibrational spectroscopy. Stereochemistry of transition metal complexes and introduction to organometallics.
CHEM 173B. Advanced Inorganic Chemistry
(3) STAFF
Prerequisite: Chemistry 173A.
Enrollment Comments: Designed for majors. Concurrently offered with Chemistry 268B. Quarters usually offered: Winter.
Structures of ordered crystalline solids, X-Ray crystallography. Introduction to solid state chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry.
CHEM 175. Physical-Inorganic Chemistry
(3) STAFF
Prerequisite: Chemistry 173A-B.
Enrollment Comments: Offered concurrently with Chemistry 275.
Bonding theory, thermodynamics, and structure of inorganic compounds. Applications of physical techniques to the study of inorganic (and organometallic) reactions and their mechanisms.
CHEM 176. Photochemical and Photophysical Properties of Inorganic and Organometallic Compounds and Materials
(3) FORD, STUCKY, WATTS
Prerequisite: Chemistry 173A.
Enrollment Comments: Offered concurrently with Chemistry 276.
Discussion of the mechanisms of fundamental physical and chemical events which follow absorption of light by inorganic and organometallic chromophores. Consideration of homogeneous and heterogeneous systems as well as the design and operation of photo-optical and photoelectrical devices.
CHEM 181. Protein Crystallography
(3) KOHLSTAEDT, PERONA
Prerequisite: Consent of instructor.
Introduction to diffraction techniques. Protein crystal growth and morphology. Data collection and reduction strategies. Approaches for solving the phase problem. Crystallographic refinement, including molecular dynamics. Interpretation of crystal structures.
CHEM 183. Introduction to Teaching in Chemistry
(1-5) STAFF
Prerequisite: Upper-division standing, a chemistry grade point average of 3.5 or above and consent of instructor.
Enrollment Comments: May be repeated for credit to a maximum of 5 units. May not be applied toward the major.
Students will assist the teaching assistant in teaching a lab course in which the student previously received a grade of A- or better. Activities will be determined in consultation with the instructor and include instruction of 1 or 2 lab sections per week. Undergraduates enrolled in Chem 183 are learning assistants (LAs) in the general chemistry laboratory. LAs teach and mentor first-year university students. LAs assist students with experiments, lab technique, data analysis, calculations, learning chemistry concepts, and problem solving. As the LAs learn STEM education pedagogy, they can practice what they learn as LAs in the chemistry lab.
CHEM 184. Chemical Literature
(2) HUBER
Prerequisite: 3 prior courses in chemistry.
Lectures and exercises on the literature and other information resources of use in chemistry.
CHEM 186. Organometallic Chemistry: Structure, Bonding, and Applications
(3) STAFF
Prerequisite: Chem 173A.
Enrollment Comments: Concurrently offered with Chem 286.
Synthesis, structure, and reactivity of organometallic complexes, with an emphasis on bonding and electronic structure. Homogeneous catalysis and small molecule activation, especially in the context of the energy conversion and storage, will also be discussed.
CHEM 192. Honors Research Seminar
(3) STAFF
Prerequisite: Upper-division standing; consent of instructor and department.
Enrollment Comments: Students must have a minimum 3.5 GPA. No units may be applied to the major. An application must be completed and submitted to the undergrad advisor early in the first quarter of the senior year. Students successfully completing the program are eligible to graduate with Distinction in the Major.
Independent research project carried out under the supervision of faculty member. Goal is to write an original, publishable, research paper. The project can be on a topic of the student's choice, or it can be an extension of an ongoing research project under the direction of a faculty member in the department.
CHEM 193. Internship in Chemistry
(1-4) STAFF
Prerequisite: Chem 1AL, 1BL, 1CL, and consent of Chem instructor.
Enrollment Comments: Designed for majors. Students must have a minimum 3.0 GPA. No units may be applied to the major. An application must be completed and submitted to the department chair.
Opportunity to obtain practical non paid chemistry-related research and work experience by working under faculty and/or staff direction as an intern.
CHEM 196. Special Topics
(1-4) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: Chem 196 may apply to major requirements by petition only.
Special topics and courses as a means of meeting special curriculum needs.
CHEM 198. Research in Chemical Education
(1-5) STAFF
Prerequisite: Upper-division standing in a physical science, life science, or engineering major
Enrollment Comments: Students must have a minimum 3.0 GPA for the preceding 3 quarters and are limited to 5 units per quarter and 30 units total in all 98/99/198/199/199AA-ZZ courses combined.
Coursework shall consist of research in chemical education supervised by a faculty member. This course is not intended for internship credit.
CHEM 199. Independent Studies
(1-5) STAFF
Prerequisite: Upper-division standing in the major; completion of two upper division courses in chemistry.
Enrollment Comments: Students must have a minimum 3.0 GPA for the preceding 3 quarters and are limited to 5 units per quarter and 30 units total in all 98/99/198/199/199AA-ZZ courses combined.
Coursework shall consist of academic research supervised by a faculty member. This course is not intended for internship credit.
Collapse Courses Graduate 
CHEM 204. Advanced Science and Engineering of Energy Conversion
(3) MCFARLAND
Enrollment Comments: Same course as Ch E 241.
The course provides a framework for understanding the energy supply issues facing society with a focus on the science, engineering, and economic principles of the major alternatives. Emphasis will be on the physical and chemical fundamentals of energy conversion technologies.
CHEM 217A. Statistical Mechanics
(3) BROWN, METIU, SHEA
Prerequisite: Consent of graduate advisor.
Enrollment Comments: Not open for credit to students who have completed Chemistry 117A.
Fundamentals of statistical thermodynamics, partition functions for ideal gases and crystals, quantum statistics, calculations of thermodynamic properties.
CHEM 217B. Statistical Mechanics
(3) STAFF
Prerequisite: Consent of graduate advisor.
Fundamentals of non-equilibrium statistical mechanics, kinetic theory of gases, Boltzmann equation, correlation functions, linear response theory, fluctuation-dissipation theorem, Langevin and Fokker- Planck equations.
CHEM 217C. Statistical Mechanics
(3) BROWN, METIU, SHEA
Prerequisite: Consent of graduate advisor.
Selected topics in advanced statistical mechanics. Phase transitions and the renormalization group. Theory of rate processes.
CHEM 218. Photochemistry and Radiation Chemistry
(3) BURATTO
Prerequisite: Open only by consent of the chemistry graduate advisor.
Interaction of light and matter, reaction paths from electonically excited molecules, flash photolysis, high energy radiation.
CHEM 219. Selected Topics in Physical Chemistry
(1-4) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: Course may be repeated with a different topic (18 units maximum).
Selected topics: orbital symmetry rules for chemical reactions (Pearson); classical theory of light, radiation, and spectroscopy (Metiu); nonlinear optics and nonlinear spectroscopy (Metiu).
CHEM 222A. Fundamentals of Quantum Chemistry
(3) STAFF
Prerequisite: Graduate standing.
Enrollment Comments: Not open for credit to students who have completed Chemistry 115A-B-C.
Introduction to quantum mechanics-postulatory approach; particle in box, on ring, harmonic oscillator; lineral operator theory, matrix algebra; hydrogen atom; perturbation theory, variation theory; applications.
CHEM 222B. Fundamentals of Quantum Chemistry
(3) STAFF
Prerequisite: Graduate standing.
Enrollment Comments: Not open for credit to students who have completed Chemistry 115A-B-C.
Molecular Orbital theory and Valence Bond theory (Secular Equ.) applications to conjugated systems, electronic spectra, and term symbols; introduction to infrared, raman, and microwave spectroscopy.
CHEM 222C. Fundamentals of Quantum Chemistry
(3) STAFF
Prerequisite: Graduate standing.
Enrollment Comments: Not open for credit to students who have completed Chemistry 115A-B-C.
Introduction to NMR, EPR, group theory; applications.
CHEM 223. Current Events in Organic Chemistry
(2) STAFF
Recommended Preparation: Chemistry 109A-B-C.
Faculty and students present and critically discuss current chemical literature.
CHEM 224. Organic Spectroscopic Analysis
(3) STAFF
Structure determination of complex organic molecules. Topics include NMR, IR, UV, and mass spectrometry.
CHEM 225. Instrumental Methods in Physical Chemistry
(3) BOWERS, WODTKE
Prerequisite: Consent of instructor.
Enrollment Comments: May be repeated with different topics to a maximum of nine units. Advanced undergraduates may enroll by petition to their college office.
Fundamentals of basic measurements and advanced research instrumentation are taught. Emphasis is on both practical and conceptual understanding of the methods, suitable for experimental design. Signal electronics, vacuum techniques, molecularbeams, lasers, and optics.
CHEM 226. Computational Chemistry
(3) AUE, GERIG
Introduction to computational chemistry and molecular modeling. Applications of molecular mechanics, quantum mechanics, and computer graphical interfaces to problems in chemistry, biochemistry, drug design, and pharmacology.
CHEM 227. Structure and Reactivity in Organic Chemistry
(3) STAFF
Electronic structure, resonance, acid/base chemistry, thermodynamics, kinetics, transition state theory, and isotope effects.
CHEM 228. Organic Reaction Mechanisms
(3) STAFF
Mechanisms of thermal, photochemical, organometallic, electrochemical, asymmetric or other processes in organic chemistry.
CHEM 229. Synthetic Organic Reactions
(3) STAFF
A survey of reactions of organic substances with emphasis on those with practical synthetic utility, including discussion of mechanism, scope and limitations, and stereochemical issues.
CHEM 232. Organometallics in Organic Synthesis
(3) STAFF
Prerequisite: Chemistry 129 or 229; graduate standing.
Recommended Preparation: Chemistry 233.
Enrollment Comments: Designed for majors. Concurrently offered with 132. Quarters usually offered: Spring.
Synthetic methods and applications to natural products total syntheses involving transition metals.
CHEM 233. Advanced Synthetic Chemistry
(3) STAFF
Prerequisite: Consent of instructor.
A comprehensive discussion of modern synthetic organic methods, including the applications of addition, condensation, substitution, and rearrangement reactions.
CHEM 234. Chemical Synthesis of Biological Molecules
(3) STAFF
Prerequisite: Chemistry 229; graduate standing; consent of instructor.
Enrollment Comments: Concurrently offered with CHEM 134. Quarters usually offered: Spring.
The synthesis, manipulation, and modification of biological molecules including peptides, carbohydrates, nucleic acids, and other metabolites are essential to advances in biomedicine. This course surveys chemical methods for the production of these molecules and their application to biological problems.
CHEM 239AAZZ. Selected Topics in Organic Chemistry
(1-4) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: May be repeated provided topics are different. Only 18 units of total credit may apply to the major.
Selected topics from organic chemistry the contents of this course will vary.
CHEM 239AA. Complex Molecule Synthesis
CHEM 239YY. Methods for Asymmetric Synthesis
CHEM 240. Chemistry of Organic Semiconductors
(4) BAZAN
Synthesis, electronic structure, photophysics and applications of organic semiconductors. Emphasis will be placed on materials based on conjugated polymers. Applications of interest include solar cell devices, biosensors, and light emitting diodes.
CHEM 241. Epigenetics: Biology, Mechanisms and Therapies
(3) STAFF
Prerequisite: Chemistry W142A or 142A, 142B-C; or, MCDB 108A-B-C; graduate standing.
Covers epigenetic processes and molecular mechanisms in bacteria, fungi, plants, mammals, imprinting, gene regulation, repeat-induced point mutation (RIP), X- chromosome inactivation, epigenetic mechanisms including DNA methylation, histone modification, chromatin remodeling, RNA silencing, and epigentically based therapeutics and pharmaco-epigenetics.
CHEM 242A. Chemical Aspects of Biological Systems
(3) STAFF
Prerequisite: Open only by consent of the chemistry graduate advisor.
Macromolecules of biological importance. A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of biomolecules.
CHEM 242B. Chemical Aspects of Biological Systems
(3) STAFF
Prerequisite: Open only by consent of the chemistry graduate advisor.
Chemical aspects of intermediary metabolism. The chemistry and elementary dynamic properties of enzymes; study of enzyme active sites; characterization of metabolic pathways and methods of examining cellular regulation.
CHEM 242C. Chemical Aspects of Biological Systems
(3) STAFF
Prerequisite: Open only by consent of the chemistry graduate advisor.
Macromolecular biosynthesis and specialized cellular processes. A survey of nucleic acid and protein biosynthesis, characterization of lipids and membranes; function of membranes in transport, energy transduction, and cellular control; mechanisms of muscle contraction and cell motility; neurochemistry.
CHEM 243. The RNA World
(3) STAFF
Prerequisite: Chemistry W142A or 142A, 142B-C; or, MCDB 108A-B-C.
Introduction to RNA structure and thermodynamics. Biological roles of RNA in contemporary organisms. Implications for the origins of life.
CHEM 244. Informational Macro- and Supra-Molecules
(2) JAEGER
Prerequisite: Consent of instructor.
Enrollment Comments: Same course as BMSE 244.
Selected topics at the interface of chemistry and biology; informational molecular coding, molecular machines, self-assembling and self-replicating molecular systems, evolution and selection of molecules with binding and catalytic properties, biopolymer-based materials, special emphasis on cutting-edge technologies.
CHEM 245. Computational Biochemistry
(3) STAFF
Prerequisite: Chemistry 113A, 112, 142A-B-C or 113A-B-C.
Introduction to molecular modeling and molecular dynamics. Discussion of practical considerations of energy minimization, solvent modeling, structure-based drug design. Practical computer graphics experience.
CHEM 246. Membrane Biochemistry
(3) STAFF
Prerequisite: Chemistry 142A-B-C.
Enrollment Comments: Same course as BMSE 246
Introduction to the structures and roles of lipids an their behavior, liposomes, membrane proteins and kinetics, protein sorting, and signal transduction.
CHEM 248. Reaction Rate Theory
(3) PETERS
Recommended Preparation: Physical chemistry and statistical mechanics.
Enrollment Comments: Same course as Chemical Engineering 248.
Advanced theoretical and computational methods for the analysis of reaction kinetics and mechanisms. Topics include transition state theory, Kramers' theory, tunneling effects, transition state search algorithms, transition path sampling, kinetic Monte Carlo, reaction coordinate and degree-of-rate-control analyses.
CHEM 251. Post-Translational Protein Processing
(4) WAITE
Prerequisite: MCDB 108A or MCDB 218A or Chemistry 142A or equivalent.
Enrollment Comments: Same course as MCDB 245.
Structure/function relationships in interesting macromolecules isolated from marine organisms. Focus is on well-characterized pathways from horseshoe crabs, abalones, mussels, and fish as well as others.
CHEM 254A. Magnetic Resonance in Biological Systems
(3) STAFF
Prerequisite: Graduate standing.
A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.
CHEM 254B. Magnetic Resonance Techniques in Biological Systems
(3) GERIG
Prerequisite: Consent of instructor.
A discussion of the theory and practice of magnetic resonance methods currently used in studies of proteins, nucleic acids, and polysaccharides both individually and in complex structures such as membranes. nmr and epr techniques will be included but the emphasis will be on high-resolution 1H and 13C spectroscopy.
CHEM 257. Strategy in Organic Synthesis and Methodology
(3) STAFF
Prerequisite: Advancement to candidacy.
Recommended Preparation: Primarily intended for graduate students in the organic division.
Enrollment Comments: Quarters usually offered: Winter, Spring.
The design, development, presentation, and organization of new concepts for organic synthesis and methodologies is an essential skill for graduate students. Course focuses on advances in these areas and developing skills for writing and presenting research proposals.
CHEM 259. Selected Topics in Biological Chemistry
(1-4) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: Same course as BMSE 259. Course may be repeated with a different topic (18 units maximum).
Selected topics from bio-organic, biophysical, or biological chemistry. Thecontent of this course will vary.
CHEM 261. Enzyme Mechanisms
(3) PARSONS
Prerequisite: Chemistry 142A-B-C or MCDB 108A-B-C.
Chemistry, structure, and function of enzymes; theory, experimental design,and data analysis. Enzyme models and non-classical enzymes.
CHEM 262A. Drug Design
(3) KAHN, REICH
Sources for new drugs. Biochemistry of diseases. Target validation techniques. Mechanism of action of enzymes and receptors. Enzyme inhibition and receptor binding studies. Structure base drug design: conformational analysis, docking and binding affinity calculations. Course also teaches proposal writing skills.
CHEM 262B. Drug Design
(3) KAHN, REICH
Medicinal chemistry for lead optimization, combinatorial synthesis, quantitative structure-activity relationships, pharmacokinetics, drug metabolism and toxicity, pharmacogenomics. Drugs that interact with DNA and Protein drugs. Clinical trials, intellectual property in drug design. Students develop their own drug design project.
CHEM 263. Arrow Pushing in Organic Chemistry
(3) STAFF
Prerequisite: Graduate standing.
Recommended Preparation: a previous or current course in one of the following; Chemistry 227, 228, 229 or 233.
Enrollment Comments: Concurrently offered with CHEM 163.
Covers the arrow pushing fomulasism and addresses molecular rearrangements and other organic reactions from this perspective.
CHEM 264. Advanced Catalysis
(3) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: Same course as Chemical Engineering 246.
Theories of reaction rates. Heterogeneous and homogenous catalysis, including physical structure and characterization of catalysts. Catalyst poisoning.
CHEM 265. Industrial Methods for Polymer Synthesis
(3) BAZAN
Prerequisite: Graduate or senior standing.
Covers in detail the methods of polymer preparation currently practiced in industry. Special coverage of structure/property relationships in polymers, the design and mechanism of action of successful catalysts, and the transformation of basic polymerization reactions into large-scale processes.
CHEM 266. Photophysics and Device Science of Organic Materials
(3) STAFF
Prerequisite: Graduate or senior standing.
Examination of what happens when organic molecules absorb a photon or when they are incorporated within an optoelectric device. Specific subjects include phtoexcitation and relaxation processes, energy transfer, flourescence depolarization, the design of flourescence-based biosensors, organic light emitting diodes and field effect transistors.
CHEM 268A. Advanced Inorganic Chemistry
(3) STAFF
Prerequisite: Consent of the chemistry graduate advisor.
Enrollment Comments: Not open for credit to students who have completed Chemistry 173A, or 272A.
Electronic structure of atoms and molecules. Models for bonding in molecules of nontransition and transition elements. Applications of symmetry to bonding, electronic and vibrational spectroscopy. Stereochemistry of transition metal complexes and introduction to organo- metallics.
CHEM 268B. Advanced Inorganic Chemistry
(3) STAFF
Prerequisite: Consent of the chemistry graduate advisor.
Enrollment Comments: Not open for credit to students who have completed Chemistry 173B or 272B.
Structures of ordered crystalline solids, x-ray crystallography. Introduction to solid state chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry.
CHEM 270. Graduate Seminar in Inorganic/Analytical Chemistry
(2) STAFF
Prerequisite: Graduate standing.
Seminars on current research topics in inorganic/analytical chemistry presented by faculty, visiting scholars, and postdoctoral and senior graduate students.
CHEM 271. Bioinorganic Chemistry
(3) BUTLER, FORD
Prerequisite: Chemistry 173A-B or the equivalent.
Selected topics in bioinorganic chemistry and metal-lobiochemistry with a major focus on recent developments. Topics will include discussions of metalloproteins and corresponding model compound investigations. Emphasis will be on reaction mechanisms and spectroscopic properties of metal sites.
CHEM 271A. Synthesis and Properties of Macromolecules
(3) STAFF
Prerequisite: Consent of instructor.
Basics of preparation of polymer and macromolecular assemblies, and characterization of large molecules and assemblies. Discussion of chemical structure, bonding, and reactivity.
CHEM 272. Reaction Mechanisms in Organometallic and Inorganic Chemistry
(3) STAFF
Prerequisite: Chemistry 173A-B, or equivalent.
Discussion of chemical reaction mechanisms. Emphasis will be on fundamental reactions of metal compounds such as substitution, addition, elimination, and redox reactions for homogenous catalysis mechanisms and other complex systems.
CHEM 273. Structural Inorganic Chemistry
(3) STAFF
Prerequisite: Chemistry 173A-B, and 175; or equivalent.
Enrollment Comments: Same course as Materials 241.
The use of x-ray and neutron scattering to characterize solid state materials. Subjects include the crystal unit cell, space groups, structure determination and refinement. It is recommended that the student have an elementary introduction to vectors, matrices and fourier series.
CHEM 274. Solid State Inorganic/Materials
(3) STAFF
Prerequisite: Chemistry 173A-B or equivalent.
Enrollment Comments: Same course as Materials 274.
An introductory course describing the synthesis, physical characterization, structure, electronic properties and uses of solid state materials.
CHEM 275. Physical-Inorganic Chemistry
(3) STAFF
Bonding theory, thermodynamics, and structure of inorganic compounds. Applications of physical techniques to the study of inorganic (and organometallic) reactions and their mechanisms.
CHEM 276. Photochemical and Photophysical Properties of Inorganic and Organometallic Compounds and Materials
(3) STAFF
Prerequisite: Chemistry 173A-B or equivalent.
Discussion of the mechanics of fundamental physical and chemical events which follow absorption of light by inorganic or organometallic chromophores. Consideration of homogeneous and heterogeneous systems as well as the design and operation of photo-optical and photoelectrical devices.
CHEM 277. Introduction to Inorganic Materials
(3) STAFF
Enrollment Comments: Same course as Materials 218.
Structures of inorganic materials: close-packing, linking of simple polyhedra. Factors that control structure: ionic radii, covalency, ligand field effects, metal-metal bonding, electron/ atom ratios. Structure-property relationships in e.g. spinels, garnets, perovskites, rutiles, flourites, zeolites, b- aluminas, graphites, common inorganic glasses.
CHEM 279. Selected Topics in Inorganic Chemistry
(1-4) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: Course may be repeated with a different topic (18 units maximum).
This course is designed to reflect recent developments in inorganic chemistry.
CHEM 281. Protein Crystallography
(3) STAFF
Prerequisite: Consent of instructor.
Introduction to diffraction techniques. protein crystal growth and morphology. Data collection and reduction strategies. Approaches for solving the phase problem. Crystallographic refinement, including molecular dynamics. Interpretation of crystal structures.
CHEM 282A. Synthesis and Bonding of Small Conjugated Molecules
(3) STAFF
Enrollment Comments: Designed for majors.
Examination of small organic molecules used in optoelectronic devices: film transistors; light emitting diodes and solar cells. Methods for their synthesis. Influence of molecular structure on energies of molecular orbitals. Development of structure/function relationships based on solid state arrangements.
CHEM 282B. Organic Semiconductors for Energy Conversion
(3) STAFF
Enrollment Comments: Designed for majors.
Basic photophysics of organic semiconductors. Examination of energy level alignments and solid state arrangements required for the conversion of solar energy into useful electrical energy. Important device considerations for evaluating power conversion efficiencies. Comparison of different solar conversion technologies.
CHEM 282C. Instrumental Methods in Materials Chemistry
(3) NGUYEN, BURATTO, SESHADRI
Prerequisite: Chemistry 109A-B-C and Physics 6A-B-C
Enrollment Comments: Designed for majors.
Principles and practice of advanced research instrumentation for soft materials characterization including spectroscopy, microscopy, and X-ray techniques
CHEM 284. Chemical Literature
(2) STAFF
Enrollment Comments: Does not count toward core academic units for the Chemistry PhD program.
Lectures and exercises on the literature and other information resources of use in chemistry.
CHEM 285. Synthetic Chemistry of Macromolecules
(3) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: Same course as Materials 284.
Molecular architecture and classifica tion of macromolecules. Different methods for the preparation of polymers: free radical polymerization, ionicpolymerization, condensation polymerization and coordination polymerization. bulk, solution, and emulsion polymerization. Principles of copolymerization, blockcopolymerization, grafting, network formation, chemical reactions on polymers.
CHEM 286. Organometallic Chemistry: Structure, Bonding, and Applications
(3) STAFF
Prerequisite: Chem 173A or 268A.
Enrollment Comments: Concurrently offered with Chem 186.
Synthesis, structure, and reactivity of organometallic complexes, with an emphasis on bonding and electronic structure. Homogeneous catalysis and small molecule activation, especially in the context of the energy conversion and storage, will also be discussed. Graduate students will be required to demonstrate a deeper understanding of the course material during class discussions and in submitted work. Graduate students will additionally be graded separately on all course work, including exams.
CHEM 290. Seminar in Chemistry and Biochemistry
(2) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: May be repeated for credit.
Presentation of seminar required of all departmental graduate students.
CHEM 291. Special Seminar in Chemistry
(2) STAFF
Prerequisite: Consent of instructor.
Enrollment Comments: May be repeated for credit.
Specialized seminar topics.
CHEM 293. Faculty Research Seminar
(2) STAFF
Prerequisite: Consent of instructor.
A series of seminars by departmental faculty describ ing their active research projects.
CHEM 501A. Techniques of Teaching and Laboratory Class Supervision
(2) STAFF
Prerequisite: Graduate standing.
Enrollment Comments: S/U grade.
An initial two-three day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants.
CHEM 501B. Techniques of Teaching and Laboratory Class Supervision
(2) STAFF
Prerequisite: Graduate standing.
Enrollment Comments: S/U grade.
An initial two-three day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants.
CHEM 501C. Techniques of Teaching and Laboratory Class Supervision
(2) STAFF
Prerequisite: Graduate standing.
Enrollment Comments: S/U grade.
An initial two-three day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants.
CHEM 502A. Organic Chemistry Techniques of Teaching and Laboratory Class Supervision
(2) STAFF
Prerequisite: Graduate standing.
Enrollment Comments: S/U grade.
An initial two-three day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants in Organic Chemistry.
CHEM 502B. Organic Chemistry Techniques of Teaching and Laboratory Class Supervision
(2) STAFF
Prerequisite: Graduate standing.
Enrollment Comments: S/U grade.
An initial two-three day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants in Organic Chemistry.
CHEM 502C. Organic Chemistry Techniques of Teaching and Laboratory Class Supervision
(2) STAFF
Prerequisite: Graduate standing.
Enrollment Comments: S/U grade.
An initial two-three day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants in Organic Chemistry.
CHEM 595. Group Studies
(2) STAFF
Critical review of research in selected fields. Regular meetings are held in which the student presents for discussion information from the recent chemical literature.
CHEM 596. Directed Reading and Research
(2-12) STAFF
Enrollment Comments: No more than half the units necessary for the master's degree may be taken in Chemistry 596. Same course as BMB 596.
Individual tutorial. Instructor is usually the student's major research advisor. Each faculty member has a unique number designation.
CHEM 597. Individual Study for Master's Comprehensive Examinations and Ph.D. Examinations.
(1-3) STAFF
Enrollment Comments: No unit credit allowed toward advanced degree(s).
Instructor should be the student's major professor or chairman of the doctoral committee.
CHEM 598. Master's Thesis Research and Preparation
(1-12) STAFF
Enrollment Comments: No unit credit will be given.
Only for research underlying the thesis, writing the thesis. Instructor should be the chairman of the student's thesis committee.
CHEM 599. Ph.D. Dissertation Research and Preparation
(1-12) STAFF
Only for research underlying the dissertation, writing the dissertation. Instructor should be the chair of the student's doctoral committee.

 
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CHEM W 109C. Organic Chemistry
(4) STAFF
Prerequisite: Chemistry 109B or 109BH with a minimum grade of C-.
Enrollment Comments: This is an online version of the regular CHEM 109C. Not open for credit to students who have completed CHEM 107C or CHEM 109CH or CHEM 109C. These courses also may not be taken concurrently.
Repeat Comments: CHEM W 109C is a legal repeat of CHEM 109C.
Structure, reactivity and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acides, proteins, nucleic acids, coenzymes and their mechanisms.
CHEM W 142A. Biochemistry
(3) STAFF
Prerequisite: Chemistry 107A-B-C or 109A or 109AH-109B or 109BH-109C or 109CH or W 109C
Enrollment Comments: Quarters usually offered: Summer.
Macromolecules of biological importance. A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of biomolecules.